{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:45:42Z","timestamp":1787021142904,"version":"build-2736575974"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,3,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Prospective Oral Mucositis Audit assessed the incidence, duration, and determinants of severe oral mucositis (OM; WHO oral toxicity scale grades 3 to 4) in patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) receiving high-dose conditioning chemotherapy before autologous stem-cell transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients with MM (n = 109; mean age, 57 \u00b1 8 years) or NHL (n = 88; mean age, 50 \u00b1 13 years) were treated with high-dose melphalan (200 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) or carmustine 300 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , etoposide 800 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , cytarabine 800 to 1,600 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and melphalan 140 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      chemotherapy, respectively, in 25 European centers. OM assessments were made daily until 30 days after transplantation or hospital discharge. High quality of OM assessment was ensured by an intensive training program.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Severe OM occurred in 46% (95% CI, 36% to 56%) of patients with MM and 42% (95% CI, 32% to 53%) of patients with NHL, with a mean duration of 5.3 days (95% CI, 4.4 to 6.1 days) and 5.5 days (95% CI, 4.5 to 6.7 days), respectively. Time from start of conditioning to peak OM score was 12.1 \u00b1 2.6 and 14.6 \u00b1 2.4 days. Severe OM risk and\/or duration was significantly associated with higher chemotherapy dose per kilogram of body weight and poor performance status, but in contrast with some previous reports, this was not related to age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe OM is more common in the transplantation setting than previously reported, justifying effective preventative and therapeutic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2007.13.6028","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T21:40:28Z","timestamp":1202766028000},"page":"1519-1525","source":"Crossref","is-referenced-by-count":162,"title":["Prospective Oral Mucositis Audit: Oral Mucositis in Patients Receiving High-Dose Melphalan or BEAM Conditioning Chemotherapy\u2014European Blood and Marrow Transplantation Mucositis Advisory Group"],"prefix":"10.1200","volume":"26","author":[{"given":"Nicole","family":"Blijlevens","sequence":"first","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schwenkglenks","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bacon","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"D'Addio","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietger","family":"Niederwieser","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Rabitsch","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Roosaar","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"Ruutu","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Schouten","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Stone","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Vokurka","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Quinn","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"McCann","sequence":"additional","affiliation":[{"name":"From the Department of Hematology, University Medical Centre St Radboud, Nijmegen; University Hospital Maastricht, Maastricht, the Netherlands; European Center of Pharmaceutical Medicine, University of Basel, Basel; Amgen (Europe) GmbH, Zug, Switzerland; Institute of Hematology and Medical Oncology \u201cL. and A. Seragnoli\u201d, Bologna, Italy; Department of Internal Medicine II, University Medical Center W\u00fcrzburg; Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02202.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q"},{"key":"R3","unstructured":"McGuire DB, Altomonte V, Peterson DE, et al: Patterns of mucositis and pain in patients receiving preparative chemotherapy and bone marrow transplantation. Oncol Nurs Forum 20:1493,1993-1502,"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl332"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1318"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702447"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8340"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003440"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Bellm LA, Epstein JB, Rose-Ped A, et al: Patient reports of complications of bone marrow transplantation. Support Care Cancer 8:33,2000-39,","DOI":"10.1007\/s005209900095"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1086\/322595"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06323.x"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11671"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2201"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040125"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00033-7"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20162"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.04.030"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1188\/07.CJON.S1.3-12"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S1462-3889(07)70003-0"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20163"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705250"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.731"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi248"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008396525292"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704595"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703694"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705471"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704716"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050004"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00259-7"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.2.412"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0031-z"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1<11::AID-CNCR2820750104>3.0.CO;2-N"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-3-224"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2007.13.6028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T18:39:12Z","timestamp":1653503952000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2007.13.6028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,3,20]]}},"alternative-id":["10.1200\/JCO.2007.13.6028"],"URL":"https:\/\/doi.org\/10.1200\/jco.2007.13.6028","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]}}}