{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:11:21Z","timestamp":1791101481241,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,3,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Risk-reducing salpingo-oophorectomy (RRSO) has been widely adopted as a key component of breast and gynecologic cancer risk-reduction for women with BRCA1 and BRCA2 mutations. Despite 17% to 39% of all BRCA mutation carriers having a mutation in BRCA2, no prospective study to date has evaluated the efficacy of RRSO for the prevention of breast and BRCA-associated gynecologic (ovarian, fallopian tube or primary peritoneal) cancer when BRCA2 mutation carriers are analyzed separately from BRCA1 mutation carriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A total of 1,079 women 30 years of age and older with ovaries in situ and a deleterious BRCA1 or BRCA2 mutation were enrolled onto prospective follow-up studies at one of 11 centers from November 1, 1994 to December 1, 2004. Women self-selected RRSO or observation. Follow-up information through November 30, 2005, was collected by questionnaire and medical record review. The effect of RRSO on time to diagnosis of breast or BRCA-associated gynecologic cancer was analyzed using a Cox proportional-hazards model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During 3-year follow-up, RRSO was associated with an 85% reduction in BRCA1-associated gynecologic cancer risk (hazard ratio [HR] = 0.15; 95% CI, 0.04 to 0.56) and a 72% reduction in BRCA2-associated breast cancer risk (HR = 0.28; 95% CI, 0.08 to 0.92). While protection against BRCA1-associated breast cancer (HR = 0.61; 95% CI, 0.30 to 1.22) and BRCA2-associated gynecologic cancer (HR = 0.00; 95% CI, not estimable) was suggested, neither effect reached statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The protection conferred by RRSO against breast and gynecologic cancers may differ between carriers of BRCA1 and BRCA2 mutations. Further studies evaluating the efficacy of risk-reduction strategies in BRCA mutation carriers should stratify by the specific gene mutated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2007.13.9626","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T21:40:28Z","timestamp":1202766028000},"page":"1331-1337","source":"Crossref","is-referenced-by-count":493,"title":["Risk-Reducing Salpingo-Oophorectomy for the Prevention of BRCA1- and BRCA2-Associated Breast and Gynecologic Cancer: A Multicenter, Prospective Study"],"prefix":"10.1200","volume":"26","author":[{"given":"Noah D.","family":"Kauff","sequence":"first","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Friebel","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Robson","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Isaacs","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Lynch","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind A.","family":"Eeles","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B.","family":"Daly","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Matloff","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Blum","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sabbatini","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Barakat","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Hudis","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Norton","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; Fox Chase Cancer Center, Philadelphia, PA; Dana-Farber Cancer Institute, Boston, MA; Lombardi Comprehensive Cancer Center, Washington, DC; Manchester Regional Genetics Service, Manchester, United Kingdom; Creighton University School of Medicine, Omaha, NE; The Institute of Cancer Research, Sutton, United Kingdom; University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[{"name":"From the Memorial Sloan-Kettering Cancer Center, New York, NY; Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics University of Pennsylvania; 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