{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:16:19Z","timestamp":1779290179208,"version":"3.51.4"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To evaluate the safety and efficacy of preoperative chemoradiotherapy followed by surgical resection for superior sulcus tumors (SSTs). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with pathologically documented non\u2013small-cell lung cancer with invasion of the first rib or more superior chest wall were enrolled as eligible; those with distant metastasis, pleural dissemination, and\/or mediastinal node involvement were excluded. Patients received two cycles of chemotherapy every 4 weeks as follows; mitomycin 8 mg\/m<jats:sup>2<\/jats:sup> on day 1, vindesine 3 mg\/m<jats:sup>2<\/jats:sup> on days 1 and 8, and cisplatin 80 mg\/m<jats:sup>2<\/jats:sup> on day 1. Radiotherapy directed at the tumor and the ipsilateral supraclavicular nodes was started on day 2 of each course, at the total dose of 45 Gy in 25 fractions, with a 1-week split. Thoracotomy was undertaken 2 to 4 weeks after completion of the chemoradiotherapy. Those with unresectable disease received boost radiotherapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> From May 1999 to November 2002, 76 patients were enrolled, of whom 20 had T4 disease; 75 patients were fully assessable. Chemoradiotherapy was generally well tolerated. Fifty-seven patients (76%) underwent surgical resection, and pathologic complete resection was achieved in 51 patients (68%). There were 12 patients with pathologic complete response. Major postoperative morbidity, including chylothorax, empyema, pneumonitis, adult respiratory distress syndrome, and bleeding, was observed in eight patients. There were three treatment-related deaths, including two deaths owing to postsurgical complications and one death owing to sepsis during chemoradiotherapy. The disease-free and overall survival rates at 3 years were 49% and 61%, respectively; at 5 years, they were 45% and 56%, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This trimodality approach is safe and effective for the treatment of patients with SSTs. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.14.1911","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T23:53:05Z","timestamp":1201737185000},"page":"644-649","source":"Crossref","is-referenced-by-count":160,"title":["Phase II Trial of Preoperative Chemoradiotherapy Followed by Surgical Resection in Patients With Superior Sulcus Non\u2013Small-Cell Lung Cancers: Report of Japan Clinical Oncology Group Trial 9806"],"prefix":"10.1200","volume":"26","author":[{"given":"Hideo","family":"Kunitoh","sequence":"first","affiliation":[{"name":"From the Department of Medical Oncology and Division of Thoracic Surgery, National Cancer Center Hospital; Department of Thoracic Surgery, Tokyo Medical University; 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Department of Thoracic Surgery, Tokyo Medical University; Japan Clinical Oncology Group Data Center, Center for Cancer Control and Information Services, National Cancer Center; Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo; Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka; Pulmonary Unit, Kobe City Medical Center General Hospital, Kobe; Department of Thoracic..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Shibata","sequence":"additional","affiliation":[{"name":"From the Department of Medical Oncology and Division of Thoracic Surgery, National Cancer Center Hospital; Department of Thoracic Surgery, Tokyo Medical University; Japan Clinical Oncology Group Data Center, Center for Cancer Control and Information Services, National Cancer Center; Department of Thoracic Surgery, Cancer Institute Hospital, Tokyo; Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka; Pulmonary Unit, Kobe City Medical Center General Hospital, Kobe; 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