{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:24:34Z","timestamp":1760783074272},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We analyzed a Scandinavian population-based cohort of 2,499 female twin pairs, in which at least one had a diagnosis of breast cancer and estimated the risk of breast cancer in the sister. Using a total of 11 million individuals in Sweden with complete family links, we identified 93,448 women with breast cancer and estimated the risk of a bilateral breast cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The incidence of breast cancer in twin sisters of breast cancer patients was 0.64% per year and 0.42% per year in mono- and dizygotic twin sisters, respectively. In comparison, the risk of familial (affected first-degree relative) and nonfamilial bilateral breast cancer was 1.03% per year and 0.68% per year, respectively. Contrary to the risk of unilateral disease, the risk of cancer in the nonaffected twin and the opposite breast was not affected by age or time since first event. The relative risk of familial bilateral cancer was 52% higher (incidence rate ratio [IRR] = 1.52; 95% CI, 1.42 to 1.64) and the relative risk in the dizygotic twin sister was 25% lower (IRR = 0.75; 95% CI, 0.61 to 0.91) compared with the risk of nonfamilial bilateral cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The elevated risk of breast cancer in high-risk groups is little affected by age and time since diagnosis. Our findings suggest that susceptible groups of women might have already aggregated genetic prerequisites for breast cancer. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.14.3198","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T01:10:01Z","timestamp":1214874601000},"page":"4086-4091","source":"Crossref","is-referenced-by-count":10,"title":["Breast Cancer Onset in Twins and Women With Bilateral Disease"],"prefix":"10.1200","volume":"26","author":[{"given":"Mikael","family":"Hartman","sequence":"first","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hall","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Reilly","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Lindstrom","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Kaprio","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Skytthe","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Peto","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[{"name":"From the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet; Department of Surgery, South Hospital, Stockholm, Sweden; Department of Public Health, University of Helsinki; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland; The Danish Twin Registry, University of Southern Denmark, Odense, Denmark; Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London; and the Section of Epidemiology,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06524-2"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10332"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70174-1"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/ng853"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/nature05887"},{"key":"R7","unstructured":"Chen Y, Thompson W, Semenciw R, et al: Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev 8:855,1999-861,"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1038\/82533"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11478"},{"key":"R11","unstructured":"Cederl\u00f6f R, Lorich U: The Swedish Twin Registry. Prog Clin Biol Res 24:189,1978-195,"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1375\/136905202320906084"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1375\/twin.9.6.763"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300012749"},{"key":"R16","unstructured":"Kyvik KO, Christensen K, Skytthe A, et al: The Danish Twin Register. Dan Med Bull 43:467,1996-470,"},{"key":"R17","unstructured":"Kaprio J, Sarna S, Koskenvuo M, et al: The Finnish Twin Registry: Formation and compilation, questionnaire study, zygosity determination procedures, and research program. Prog Clin Biol Res 24 Pt B  :179,1978-184,"},{"key":"R19","unstructured":"Clemmesen J: Statistical Studies in the Aetiology of Malignant Neoplasms. I. Review and Results Supplement 174. I. Acta Pathol Microbiol Scand 54:1,1965-543,"},{"key":"R20","unstructured":"Storm HH, Michelsen EV, Clemmensen IH, et al: The Danish Cancer Registry: History, content, quality and use. Dan Med Bull 44:535,1997-539,"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098430"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Cederlof R, Friberg L, Jonsson E, et al: Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genet Stat Med 11:338,1961-362,","DOI":"10.1159\/000151168"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1159\/000152964"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.5056"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1080\/02841860152619214"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065447"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03301-7"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"R33","unstructured":"Harvey EB, Brinton LA: Second cancer following cancer of the breast in Connecticut, 1935-82. Natl Cancer Inst Monogr 68:99,1985-112,"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602175"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.1.71"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09454-0"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08233-0"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22654"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030168"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701724104"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.5922"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2007.14.3198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:21:32Z","timestamp":1653510092000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2007.14.3198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,1]]},"references-count":35,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2008,9,1]]}},"alternative-id":["10.1200\/JCO.2007.14.3198"],"URL":"https:\/\/doi.org\/10.1200\/jco.2007.14.3198","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,1]]}}}