{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:26:23Z","timestamp":1790879183196,"version":"4.1.0"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,7,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Patients with chronic myelogenous leukemia in accelerated phase (CML-AP) that is resistant or intolerant to imatinib have limited therapeutic options. Dasatinib, a potent inhibitor of BCR-ABL and SRC-family kinases, has efficacy in patients with CML-AP who have experienced treatment failure with imatinib. We now report follow-up data from the full patient cohort of 174 patients enrolled onto a phase II trial to provide a more complete assessment of the efficacy and safety of dasatinib in this population. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with imatinib-resistant (n = 161) or -intolerant (n = 13) CML-AP received dasatinib 70 mg orally twice daily. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At a median follow-up of 14.1 months (treatment duration, 0.1 to 21.7 months), major and complete hematologic responses were attained by 64% and 45% of patients, respectively, and major and complete cytogenetic responses were achieved in 39% and 32% of patients, respectively. Responses were achieved irrespective of imatinib status (resistant or intolerant), prior stem-cell transplantation, or the presence of prior BCR-ABL mutation. The 12-month progression-free survival and overall survival rates were 66% and 82%, respectively. Dasatinib was generally well tolerated; the most frequent nonhematologic severe treatment-related adverse event was diarrhea (52%; grade 3 to 4, 8%). Cytopenias were common, including grade 3 to 4 neutropenia (76%) and thrombocytopenia (82%). Pleural effusion occurred in 27% of patients (grade 3 to 4, 5%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Dasatinib is effective in patients with CML-AP after imatinib treatment failure. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.14.3339","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T00:36:01Z","timestamp":1243902961000},"page":"3472-3479","source":"Crossref","is-referenced-by-count":155,"title":["Dasatinib in the Treatment of Chronic Myeloid Leukemia in Accelerated Phase After Imatinib Failure: The START A Trial"],"prefix":"10.1200","volume":"27","author":[{"given":"Jane F.","family":"Apperley","sequence":"first","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Cortes","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Roy","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail J.","family":"Roboz","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianantonio","family":"Rosti","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo O.","family":"Bullorsky","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. 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Anderson Cancer Center, Houston, TX; St Mary's Hospital, the Catholic University of Korea, Seoul; Chonnam National University, Hwasun-gun, Jeollanam-do, Korea; Clinical Research Center, Centre Hospitalier Universitaire de Poitiers, Poitiers, France; Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY; S Orsola-Malpighi University Hospital, Bologna; Ospedale S...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Heim","sequence":"additional","affiliation":[{"name":"From the Hammersmith Hospital, Imperial College, London, United Kingdom; The University of Texas M. D. 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