{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:34:35Z","timestamp":1790778875434,"version":"4.1.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,5,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Histologic results of complete para-aortic lymphadenectomy were studied in patients treated for stage IB2\/II cervical carcinoma who had no para-aortic uptake on [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose positron emission tomography combined with integrated computed tomography (FDG-PET\/CT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients were treated between 2004 and 2006 for stage IB2\/II cervical cancer. Magnetic resonance imaging of the abdomen and pelvis and FDG-PET\/CT were initially performed. Patients with no para-aortic abnormalities were treated with external pelvic radiation therapy and concomitant chemotherapy followed by utero-vaginal brachytherapy. Para-aortic lymphadenectomy was then performed. FDG-PET\/CT images were reviewed by two nuclear medicine specialists. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Thirty-eight patients were studied. Three patients had histologically proven para-aortic involvement (metastatic nodes with capsular rupture in the para-aortic area), leading to a negative predictive value of 92% for para-aortic nodal involvement. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In this study, three of 38 patients with no para-aortic uptake on [<jats:sup>18<\/jats:sup>F]FDG-PET\/CT imaging had histologically proven para-aortic node involvement. PET\/CT imaging without histologic examination of the para-aortic area used to determine radiation therapy fields in stage IB2\/II cervical cancer would overlook 8% of patients with histologic para-aortic nodal involvement. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.14.3933","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T22:38:48Z","timestamp":1210977528000},"page":"2558-2561","source":"Crossref","is-referenced-by-count":80,"title":["Histologic Results of Para-Aortic Lymphadenectomy in Patients Treated for Stage IB2\/II Cervical Cancer With Negative [<sup>18<\/sup>F]Fluorodeoxyglucose Positron Emission Tomography Scans in the Para-Aortic Area"],"prefix":"10.1200","volume":"26","author":[{"given":"Mathias","family":"Boughanim","sequence":"first","affiliation":[{"name":"From the Departments of Surgery, Nuclear Medicine, Statistics, Pathology, and Radiation Therapy, Institut Gustave Roussy, and University Paris Sud, Villejuif, 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