{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:27Z","timestamp":1787021187867,"version":"build-2736575974"},"reference-count":23,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,7,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the sensitivity and accuracy of endobronchial ultrasound\u2013guided transbronchial needle aspiration (EBUS-TBNA) for restaging the mediastinum after induction chemotherapy in patients with non\u2013small-cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>One hundred twenty-four consecutive patients with tissue-proven stage IIIA-N2 disease who were treated with induction chemotherapy and who had undergone mediastinal restaging by EBUS-TBNA were reviewed. On the basis of computed tomography, 58 patients were classified as having stable disease and 66 were judged to have had a partial response. All patients subsequently underwent thoracotomy with attempted curative resection and a lymph node dissection regardless of EBUS-TBNA findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Persistent nodal metastases were detected by using EBUS-TBNA in 89 patients (72%). Of the 35 patients in whom no metastases were assessed by EBUS-TBNA, 28 were found to have residual stage IIIA-N2 disease at thoracotomy. The majority (91%) of these false negative results were due to nodal sampling error rather than detection error. Overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of EBUS-TBNA for mediastinal restaging after induction chemotherapy were 76%, 100%, 100%, 20%, and 77%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EBUS-TBNA is a sensitive, specific, accurate, and minimally invasive test for mediastinal restaging of patients with NSCLC. However, because of the low negative predictive value, tumor-negative findings should be confirmed by surgical staging before thoracotomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2007.14.9229","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T21:09:57Z","timestamp":1212440997000},"page":"3346-3350","source":"Crossref","is-referenced-by-count":210,"title":["Endobronchial Ultrasound With Transbronchial Needle Aspiration for Restaging the Mediastinum in Lung Cancer"],"prefix":"10.1200","volume":"26","author":[{"given":"Felix J.F.","family":"Herth","sequence":"first","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke T.","family":"Annema","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yasufuku","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Ernst","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krasnik","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Rintoul","sequence":"additional","affiliation":[{"name":"From the Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Germany; Division of Pulmonary Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan; Interventional Pulmonology, Pulmonary and Critical Care Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Surgical Gastroenterology, Gentofte University..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01585-X"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.040"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh435"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.5235"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01437-5"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(02)00101-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.10.045"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03647-0"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6341"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-919103"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.1_suppl.157S"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03257-X"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2003.381"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.031"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01457-7"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00332-4"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.047829"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.07.013"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.6.1228"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(03)00364-7"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1159\/000091533"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00095404"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2007.14.9229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T16:18:57Z","timestamp":1653495537000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2007.14.9229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,10]]},"references-count":23,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2008,7,10]]}},"alternative-id":["10.1200\/JCO.2007.14.9229"],"URL":"https:\/\/doi.org\/10.1200\/jco.2007.14.9229","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,10]]}}}