{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:54:24Z","timestamp":1783698864966,"version":"3.55.0"},"reference-count":17,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,10,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> This retrospective multicenter study assessed the outcome of 51 patients with myeloid sarcoma (MS) who underwent allogeneic hematopoietic stem-cell transplantation (alloHSCT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Most patients had MS presenting in conjunction with acute myeloid leukemia (AML) or after AML. Six patients had isolated MS. The median time between diagnosis and alloHSCT was 8 months (range, 2.8 to 67). Forty patients were in complete remission (CR) at time of alloHSCT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> With a median follow-up of 33 (range, 1 to 182) months, the Kaplan-Meier estimates of overall survival (OS) and disease-free survival were 47% (95% CI, 33% to 61%) and 36% (95% CI, 24% to 50%) at 5 years. Twenty patients (39%) relapsed at a median of 204 (range, 35 to 1151) days after alloHSCT, with relapse being the major cause of death. In a Cox multivariate analysis, age \u2265 15 years and remission status at time of alloHSCT (CR v other) were associated with improved OS (hazard ratio [HR], 0.27; 95% CI, 0.12 to 0.65; P = .003; and HR, 0.22; 95% CI, 0.08 to 0.57; P = .002, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> We conclude that first-line alloHSCT performed early in the course of MS is a valid therapeutic option. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2007.15.6315","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T01:09:10Z","timestamp":1215479350000},"page":"4940-4943","source":"Crossref","is-referenced-by-count":87,"title":["Allogeneic Hematopoietic Stem-Cell Transplantation for Myeloid Sarcoma: A Retrospective Study From the SFGM-TC"],"prefix":"10.1200","volume":"26","author":[{"given":"Patrice","family":"Chevallier","sequence":"first","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lioure","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Michel","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Contentin","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deconinck","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bordigoni","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Vernant","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Hunault","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Vigouroux","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; 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Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Volteau","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; Cellule de Promotion \u00e0 la Recherche Clinique, CHU Hotel-Dieu, Nantes; CHU Haute-Pierre, Strasbourg; Hopital de la Timone; Institut Paoli-Calmette, Marseille; Centre Henri-Becquerel, Rouen; CHU Minjoz, Besan\u00e7on; CHU de Brabois, Nancy; AP-HP, CHU de la Piti\u00e9-Salpetri\u00e8re; AP-HP, Hopital Necker; AP-HP, CHU Saint-Louis, Paris; CHU d'Angers, Angers; CHU Pontchaillou, Rennes; CHU Haut-Lev\u00eaque, Bordeaux; and CHU Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Harousseau","sequence":"additional","affiliation":[{"name":"From the Centre Hospitalier Universitaire (CHU) H\u00f4tel-Dieu; 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