{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:21:30Z","timestamp":1790842890470,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,8,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Treatment of childhood relapsed acute lymphoblastic leukemia (ALL) remains a significant challenge. The goal of the Children's Oncology Group (COG) AALL01P2 study was to develop a safe and active chemotherapy reinduction platform, which could be used to evaluate novel agents in future trials. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> One hundred twenty-four patients with ALL and first marrow relapse received three, 35-day blocks of reinduction chemotherapy: 69 with early relapse (ER; &lt; 36 months from initial diagnosis) and 55 with late relapse (LR). Minimal residual disease (MRD) was measured by flow cytometry after each treatment block. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Second complete remission (CR2) rates at the end of block 1 in 117 assessable patients were 68% \u00b1 6% for ER (n = 63) and 96% \u00b1 3% for LR (n = 54; P &lt; .0001). Five of seven patients with T-cell ALL (T-ALL) failed to achieve CR2. Among patients in CR2, MRD greater than 0.01% was detected at the end of block 1 in 75% \u00b1 7% of ER (n = 36) versus 51% \u00b1 8% of LR (n = 43; P = .0375) and 12-month event-free survival was 80% \u00b1 7% versus 58% \u00b1 7% in MRD-negative versus positive patients (P &lt; .0005). Blocks 2 and 3 of therapy resulted in reduction of MRD burden in 40 of 56 patients who were MRD positive after block 1. Toxicity was acceptable during all three blocks with five deaths (4%) from infections. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The AALL01P2 regimen is a tolerable and active reinduction platform, suitable for testing in combination with novel agents in B-precursor ALL. Alternative strategies are needed for T-ALL. Serial MRD measurements were feasible and prognostic of outcome. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.16.1414","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T22:23:22Z","timestamp":1219098202000},"page":"3971-3978","source":"Crossref","is-referenced-by-count":204,"title":["Reinduction Platform for Children With First Marrow Relapse of Acute Lymphoblastic Leukemia: A Children's Oncology Group Study"],"prefix":"10.1200","volume":"26","author":[{"given":"Elizabeth A.","family":"Raetz","sequence":"first","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Borowitz","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Linda","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J.","family":"Winick","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Camitta","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Gaynon","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD; Children's Oncology Group and University of Florida, Gainesville, FL; Department of Pediatrics, University of Colorado Denver and Health Science Center and The Children's Hospital, Aurora, CO; Department of Pediatrics, University of Texas Southwestern, Dallas, TX; Department of Pediatrics, Midwest Children's Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"From the New York University Cancer Institute and Department of Pediatrics, New York University, New York, NY; 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