{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:04:39Z","timestamp":1791821079585,"version":"4.3.4"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,9,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Identify prognostic factors that influence outcome after unrelated donor bone marrow transplantation in children with acute myeloid leukemia (AML). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Included are 268 patients (age \u2264 18 years) with AML in second complete remission (n = 142), relapse (n = 90), or primary induction failure (n = 36) at transplantation. All patients received bone marrow grafts from an unrelated donor and a myeloablative conditioning regimen. Cox regression models were constructed to identify risk factors that influence outcome after transplantation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> In this analysis, the only risk factor that predicted leukemia recurrence and overall and leukemia-free survival was disease status at transplantation. The 5-year probabilities of leukemia-free survival were 45%, 20%, and 12% for patients who underwent transplantation at second complete remission, relapse, and primary induction failure, respectively. As expected, risk of acute but not chronic graft-versus-host disease (GVHD) was lower with T-cell\u2013depleted bone marrow grafts; T-cell\u2013depleted grafts were not associated with higher risks of leukemia recurrence. We observed similar risks of leukemia relapse in patients with and without acute and chronic GVHD. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Children who underwent transplantation in remission had a superior outcome compared with children who underwent transplantation during relapse or persistent disease. Nevertheless, 20% of children who underwent transplantation in relapse are long-term survivors, suggesting that unrelated donor bone marrow transplantation is an effective therapy in a significant proportion of children with recurrent or primary refractory AML. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.16.4442","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T22:28:08Z","timestamp":1220912888000},"page":"4326-4332","source":"Crossref","is-referenced-by-count":52,"title":["Unrelated Donor Bone Marrow Transplantation for Children With Acute Myeloid Leukemia Beyond First Remission or Refractory to Chemotherapy"],"prefix":"10.1200","volume":"26","author":[{"given":"Nancy J.","family":"Bunin","sequence":"first","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aplenc","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Camitta","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"DeSantes","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Goyal","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Kapoor","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Kernan","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin O.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Eapen","sequence":"additional","affiliation":[{"name":"From the Children's Hospital of Philadelphia, Philadelphia; Children's Hospital of Pittsburgh, Pittsburgh, PA; Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee; University of Wisconsin Hospital and Clinics, Madison, WI; Children's Hospital of Los Angeles, Los Angeles; City of Hope National Medical Center, Duarte, CA; and Memorial Sloan-Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403920"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403924"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403927"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403872"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403925"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.56"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.066"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7482"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22385"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401141"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401254"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.128"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.05.007"},{"key":"R14","unstructured":"Przepiorka D, Weisdorf D, Martin P, et al: 1994 Consensus Conference on Acute GVHD Grading. 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