{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:45:43Z","timestamp":1787021143518,"version":"build-2736575974"},"reference-count":67,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2008,9,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the effectiveness of the Alleviating Depression Among Patients With Cancer (ADAPt-C) collaborative care management for major depression or dysthymia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Study patients included 472 low-income, predominantly female Hispanic patients with cancer age \u2265 18 years with major depression (49%), dysthymia (5%), or both (46%). Patients were randomly assigned to intervention (n = 242) or enhanced usual care (EUC; n = 230). Intervention patients had access for up to 12 months to a depression clinical specialist (supervised by a psychiatrist) who offered education, structured psychotherapy, and maintenance\/relapse prevention support. The psychiatrist prescribed antidepressant medications for patients preferring or assessed to require medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 12 months, 63% of intervention patients had a 50% or greater reduction in depressive symptoms from baseline as assessed by the Patient Health Questionnaire-9 (PHQ-9) depression scale compared with 50% of EUC patients (odds ratio [OR] = 1.98; 95% CI, 1.16 to 3.38; P = .01). Improvement was also found for 5-point decrease in PHQ-9 score among 72.2% of intervention patients compared with 59.7% of EUC patients (OR = 1.99; 95% CI, 1.14 to 3.50; P = .02). Intervention patients also experienced greater rates of depression treatment (72.3% v 10.4% of EUC patients; P &lt; .0001) and significantly better quality-of-life outcomes, including social\/family (adjusted mean difference between groups, 2.7; 95% CI, 1.22 to 4.17; P &lt; .001), emotional (adjusted mean difference, 1.29; 95% CI, 0.26 to 2.22; P = .01), functional (adjusted mean difference, 1.34; 95% CI, 0.08 to 2.59; P = .04), and physical well-being (adjusted mean difference, 2.79; 95% CI, 0.49 to 5.1; P = .02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADAPt-C collaborative care is feasible and results in significant reduction in depressive symptoms, improvement in quality of life, and lower pain levels compared with EUC for patients with depressive disorders in a low-income, predominantly Hispanic population in public sector oncology clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2008.16.6371","type":"journal-article","created":{"date-parts":[[2008,9,18]],"date-time":"2008-09-18T18:23:38Z","timestamp":1221762218000},"page":"4488-4496","source":"Crossref","is-referenced-by-count":229,"title":["Randomized Controlled Trial of Collaborative Care Management of Depression Among Low-Income Patients With Cancer"],"prefix":"10.1200","volume":"26","author":[{"given":"Kathleen","family":"Ell","sequence":"first","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xie","sequence":"additional","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Quon","sequence":"additional","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Quinn","sequence":"additional","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Dwight-Johnson","sequence":"additional","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pey-Jiuan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the School of Social Work and Keck School of Medicine, University of Southern California, Los Angeles, CA; and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1159\/000077742"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh014"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh026"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22980"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-8343(98)00030-9"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017942709369"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.2003.02882.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000077503.96903.A6"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52018.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.1.24"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v09n0508"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1594"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Ashbury FD, Madlensky L, Raich P, et al: Antidepressant prescribing in community cancer care. 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