{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:48:10Z","timestamp":1792036090508,"version":"4.4.0"},"reference-count":28,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,2,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Preoperative chemotherapy is an accepted standard in the treatment of localized esophagogastric adenocarcinoma. Adding radiation therapy to preoperative chemotherapy appears promising, but its definitive value remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients with locally advanced (uT3-4NXM0) adenocarcinoma of the lower esophagus or gastric cardia were randomly allocated to one of two treatment groups: induction chemotherapy (15 weeks) followed by surgery (arm A); or chemotherapy (12 weeks) followed by chemoradiotherapy (3 weeks) followed by surgery (arm B). Primary outcome was overall survival time. A total of 354 patients were needed to detect a 10% increase in 3-year survival from 25% to 35% by addition of radiation therapy. The study was prematurely closed due to low accrual.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median observation time was 46 months. A total of 126 patients were randomly assigned and 119 eligible patients were evaluated. The number of patients undergoing complete tumor resection was not different between treatment groups (69.5% v 71.5%). Patients in arm B had a significant higher probability of showing pathologic complete response (15.6% v 2.0%) or tumor-free lymph nodes (64.4% v 37.7%) at resection. Preoperative radiation therapy improved 3-year survival rate from 27.7% to 47.4% (log-rank P = .07, hazard ratio adjusted for randomization strata variables 0.67, 95% CI, 0.41 to 1.07). Postoperative mortality was nonsignificantly increased in the chemoradiotherapy group (10.2% v 3.8%; P = .26).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the study was closed early and statistical significance was not achieved, results point to a survival advantage for preoperative chemoradiotherapy compared with preoperative chemotherapy in adenocarcinomas of the esophagogastric junction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2008.17.0506","type":"journal-article","created":{"date-parts":[[2009,1,12]],"date-time":"2009-01-12T21:37:07Z","timestamp":1231796227000},"page":"851-856","source":"Crossref","is-referenced-by-count":787,"title":["Phase III Comparison of Preoperative Chemotherapy Compared With Chemoradiotherapy in Patients With Locally Advanced Adenocarcinoma of the Esophagogastric Junction"],"prefix":"10.1200","volume":"27","author":[{"given":"Michael","family":"Stahl","sequence":"first","affiliation":[{"name":"From the Departments of Medical Oncology and Hematology, and Surgery, Kliniken Essen-Mitte; Department of Radiation Oncology, and the Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen Medical School, Essen; Department of Surgery, Klinikum Solingen, Solingen; Departments of Hematology and Oncology, Surgery, and Radiation Oncology, University Clinic, Marburg; and the Department of Gastroenterology, Surgery, and Radiation Oncology, University Clinic, T\u00fcbingen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Walz","sequence":"additional","affiliation":[{"name":"From the Departments of Medical Oncology and Hematology, and Surgery, Kliniken Essen-Mitte; Department of Radiation Oncology, and the Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen Medical School, Essen; Department of Surgery, Klinikum Solingen, Solingen; Departments of Hematology and Oncology, Surgery, and Radiation Oncology, University Clinic, Marburg; and the Department of Gastroenterology, Surgery, and Radiation Oncology, University Clinic, T\u00fcbingen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stuschke","sequence":"additional","affiliation":[{"name":"From the Departments of Medical Oncology and Hematology, and Surgery, Kliniken Essen-Mitte; Department of Radiation Oncology, and the Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen Medical School, Essen; Department of Surgery, Klinikum Solingen, Solingen; Departments of Hematology and Oncology, Surgery, and Radiation Oncology, University Clinic, Marburg; and the Department of Gastroenterology, Surgery, and Radiation Oncology, University Clinic, T\u00fcbingen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Lehmann","sequence":"additional","affiliation":[{"name":"From the Departments of Medical Oncology and Hematology, and Surgery, Kliniken Essen-Mitte; Department of Radiation Oncology, and the Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg-Essen Medical School, Essen; Department of Surgery, Klinikum Solingen, Solingen; Departments of Hematology and Oncology, Surgery, and Radiation Oncology, University Clinic, Marburg; and the Department of Gastroenterology, Surgery, and Radiation Oncology, University Clinic, T\u00fcbingen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Meyer","sequence":"additional","affiliation":[{"name":"From the Departments of Medical Oncology and Hematology, and Surgery, Kliniken Essen-Mitte; 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