{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:30:15Z","timestamp":1792639815989,"version":"4.5.0"},"reference-count":58,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Peripheral T-cell lymphomas (PTCLs) are rare malignancies with poor outcome after conventional chemotherapy. The role of myeloablative therapy and autologous stem-cell transplantation (autoSCT) is still unclear. Therefore, we initiated the first prospective multicenter study on upfront autoSCT in PTCL and recently reported good feasibility and efficacy of this approach. Here, we present the final analysis of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The treatment regimen consisted of four to six cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by mobilizing therapy with either the dexamethasone, carmustine, melphalan, etoposide, and cytarabine protocol or the etoposide, methylprednisolone, cytarabine, and cisplatin protocol and stem-cell collection. Patients in complete remission (CR) or partial remission (PR) underwent myeloablative chemoradiotherapy (fractionated total-body irradiation and high-dose cyclophosphamide) and autoSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From June 2000 to April 2006, 83 patients were enrolled onto the study. Main subgroups were PTCL not specified (n = 32) and angioimmunoblastic T-cell lymphoma (n = 27). Fifty-five (66%) of the 83 patients received transplantation. The main reason for not receiving autoSCT was progressive disease. In an intent-to-treat analysis, the overall response rate after myeloablative therapy was 66% (56% CR and 8% PR). With a median follow-up time of 33 months, 43 patients are alive; the estimated 3-year overall and disease-free survival rates for patients in CR (calculated from CR to the date of relapse) and 3-year progression-free survival rate were 48%, 53%, and 36%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this prospective study suggest a substantial impact on outcome for upfront autoSCT in PTCL and should be further evaluated in randomized trials. Pretransplantation treatment needs to be improved to increase the transplantation rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2008.17.4870","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T21:26:12Z","timestamp":1227561972000},"page":"106-113","source":"Crossref","is-referenced-by-count":379,"title":["Autologous Stem-Cell Transplantation As First-Line Therapy in Peripheral T-Cell Lymphomas: Results of a Prospective Multicenter Study"],"prefix":"10.1200","volume":"27","author":[{"given":"Peter","family":"Reimer","sequence":"first","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"R\u00fcdiger","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Geissinger","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Weissinger","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Nerl","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schmitz","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Engert","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Konrad","family":"M\u00fcller-Hermelink","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"From the Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg; Pathologisches Institut, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg; Krankenhaus M\u00fcnchen-Schwabing, 1. Medizinische Abteilung, M\u00fcnchen; Allgemeines Krankenhaus St. Georg, Abteilung f\u00fcr H\u00e4matologie, Hamburg; Innere Medizin I. Medizinische Klinik der Universit\u00e4t zu K\u00f6ln, K\u00f6ln; and Med Klin 5, Klinikum N\u00fcrnberg Nord, N\u00fcrnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008200307625"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.11.3909"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1984)54:4<687::AID-CNCR2820540416>3.0.CO;2-G"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1762::AID-CNCR2820720541>3.0.CO;2-D"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00128.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00721.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.12.1783"},{"key":"R9","unstructured":"Gisselbrecht C, Gaulard P, Lepage E, et al: Prognostic significance of T-cell phenotype in aggressive non-Hodgkin's lymphomas: Groupe d'Etudes des Lymphomes de l'Adulte (GELA). Blood 92:76,1998-82,"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4514"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.436.436"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.6.2296"},{"key":"R14","unstructured":"Zaja F, Russo D, Silvestri F, et al: Retrospective analysis of 23 cases with peripheral T-cell lymphoma, unspecified: Clinical characteristics and outcome. Haematologica 82:171,1997-177,"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05478.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3913"},{"key":"R18","unstructured":"Falini B, Pileri S, Zinzani PL, et al: ALK+ lymphoma: Clinico-pathological findings and outcome. Blood 93:2697,1999-2706,"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890101)63:1<158::AID-CNCR2820630125>3.0.CO;2-B"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008418727472"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh392"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Vose JM: International Peripheral T-Cell Lymphoma (PTCL) Clinical and Pathologic Review Project: Poor outcome by prognostic indices and lack of efficacy with anthracyclines. Blood 106:239a,2005,  (suppl; abstr 811)","DOI":"10.1182\/blood.V106.11.811.811"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.2.424.424"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701596"},{"key":"R25","unstructured":"Haider K, Zamkoff K, Gentile TC: High dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) in peripheral T-cell lymphoma (PTCL): A single institution experience. Blood 94:173a,1999,  (suppl; abstr 753)"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3766"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702867"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04203.x"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg459"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1080\/10428190412331272749"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704367"},{"key":"R32","unstructured":"Schetelig J, Fetscher S, Reichle A, et al: Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation. Haematologica 88:1272,2003-1278,"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06164.x"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200359"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.16.3025"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.125"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1426"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh471"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.032"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00815.x"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1159\/000093637"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez J, Conde E, Guti\u00e9rrez A, et al: The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: The Spanish Lymphoma and Autologous Transplantation Group experience. Ann Oncol 18:652,2007-657,","DOI":"10.1093\/annonc\/mdl466"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705752"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.12.6219"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00856.x"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404306"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn022"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4458"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134270"},{"key":"R51","unstructured":"Shipp MA, Mauch PM, Harris NL: Non-Hodgkin's lymphomas, in DeVita VT, Hellmann S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology.  Philadelphia, PA, Lippincott-Raven, pp 2165,1997-2175"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11173"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3389"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.0221"},{"key":"R55","doi-asserted-by":"crossref","unstructured":"Weidmann E, Hess G, Krause SW, et al: A phase II immunochemotherapy study with alemtuzumab, fludarabine, cyclophosphamide, and doxorubicin (Campath-FCD) in peripheral T-cell lymphomas. Blood 108:769a,2006,  (suppl; abstr 2721)","DOI":"10.1182\/blood.V108.11.2721.2721"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0469-9"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074641"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.050"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2008.17.4870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:23:25Z","timestamp":1653510205000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2008.17.4870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,1]]}},"alternative-id":["10.1200\/JCO.2008.17.4870"],"URL":"https:\/\/doi.org\/10.1200\/jco.2008.17.4870","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,1]]}}}