{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:25:14Z","timestamp":1789763114134,"version":"4.0.1"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Peripheral-blood autologous stem-cell transplantation (ASCT) in patients with HIV-related lymphoma (HIV-Ly) has been reported as a safe and useful procedure. Herein we report the European Group for Blood and Marrow Transplantation experience on patients with HIV-Ly undergoing ASCT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> This was a retrospective, multicentric, registry-based analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Since 1999, 68 patients from 20 institutions (median age, 41 years; range, 29 to 62 years) were included, diagnosed with non-Hodgkin's lymphoma (NHL; n = 50) or Hodgkin's lymphoma (n = 18). At the time of ASCT, 16 patients were in first complete remission (CR1); 44 patients were in CR more than 1, partial remission, or chemotherapy-sensitive relapse (chemo-S); and eight patients had chemotherapy-resistant disease. The median number of CD34<jats:sup>+<\/jats:sup> cells infused was 4.5 \u00d7 10<jats:sup>6<\/jats:sup>\/kg (range, 1.6 to 21.2 \u00d7 10<jats:sup>6<\/jats:sup>\/kg). Median time to neutrophil and platelet engraftment were 11 days (range, 8 to 36 days) and 14 days (range, 6 to 455 days), respectively, with a cumulative incidence (CI) at 1 year of 95.6% and 87%, respectively. CI of nonrelapse mortality (NRM) was 7.5% at 12 months after ASCT, mainly because of bacterial infections. CI of relapse was 30.4% at 24 months, statistically related with not being in CR at ASCT (relative risk [RR] = 3.6), NHL histology other than diffuse large B-cell lymphoma (RR = 3.4), and use of more than two previous treatment lines (RR = 3). At a median follow-up of 32 months (range, 2 to 81 months), progression-free survival (PFS) was 56%. Patients not in CR or with refractory disease at ASCT had poorer PFS (RR = 2.4 and 4.8, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Similarly to HIV-negative patients with lymphoma, ASCT is a useful treatment for patients with HIV-Ly and is associated with low NRM, mainly when performed in early stages and chemo-S disease. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.18.2683","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T01:43:41Z","timestamp":1238463821000},"page":"2192-2198","source":"Crossref","is-referenced-by-count":98,"title":["Autologous Stem-Cell Transplantation in Patients With HIV-Related Lymphoma"],"prefix":"10.1200","volume":"27","author":[{"given":"Pascual","family":"Balsalobre","sequence":"first","affiliation":[{"name":"From the Hospital General Universitario Gregorio Mara\u00f1on, Madrid; Institut Catal\u00e1 d'Oncologia, Hospital Universitari German Trias i Pujol, Badalona; European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona; Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria, Santander; Complejo Hospitalario Juan Canalejo, A Coru\u00f1a; Hospital Universitario Virgen del Rocio, Sevilla, Spain; Spedali Civili, Brescia; Centro di Riferimento Oncologico Istituto di Ricovero e Cura..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"D\u00edez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"From the Hospital General Universitario Gregorio Mara\u00f1on, Madrid; Institut Catal\u00e1 d'Oncologia, Hospital Universitari German Trias i Pujol, Badalona; European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona; Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria, Santander; Complejo Hospitalario Juan Canalejo, A Coru\u00f1a; Hospital Universitario Virgen del Rocio, Sevilla, Spain; Spedali Civili, Brescia; 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Universitari German Trias i Pujol, Badalona; European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona; Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria, Santander; Complejo Hospitalario Juan Canalejo, A Coru\u00f1a; Hospital Universitario Virgen del Rocio, Sevilla, Spain; Spedali Civili, Brescia; Centro di Riferimento Oncologico Istituto di Ricovero e Cura..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Ribera","sequence":"additional","affiliation":[{"name":"From the Hospital General Universitario Gregorio Mara\u00f1on, Madrid; Institut Catal\u00e1 d'Oncologia, Hospital Universitari German Trias i Pujol, Badalona; European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona; Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria, Santander; Complejo Hospitalario Juan Canalejo, A Coru\u00f1a; Hospital Universitario Virgen del Rocio, Sevilla, 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