{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:15:02Z","timestamp":1792206902511,"version":"4.4.0"},"reference-count":52,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,2,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the detection rate, the false-negative rate, and the accuracy of sentinel lymph node (SLN) detection after neoadjuvant chemotherapy (NAC) for advanced breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A prospective multicentric study was initiated to evaluate the results of SLN biopsy with the combined method after NAC for advanced large operable breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From September 2003 to March 2007, 195 patients enrolled from 12 institutions were found suitable for evaluation. The detection rate was 90% (176 of 195 patients), and the false-negative rate was 11.5% (six of 52 patients). Patients without axillary palpable nodes (N0) before NAC had a better detection rate compared with patients with axillary suspicious nodes (N1, 94.6% v 81.5%; P = .008). The false-negative rate was not correlated with clinical nodal status before NAC (9.4% v 15%; P = .66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms the feasibility of SLN biopsy after NAC in the case of large operable breast cancer. The detection rate, false-negative rate, and accuracy do not differ from those obtained in the case of early breast cancer without NAC, thus demonstrating the feasibility of SLN biopsy after NAC.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.18.3228","type":"journal-article","created":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T04:54:56Z","timestamp":1230612896000},"page":"726-732","source":"Crossref","is-referenced-by-count":225,"title":["Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy for Advanced Breast Cancer: Results of Ganglion Sentinelle et Chimioth\u00e9rapie Neoadjuvante, a French Prospective Multicentric Study"],"prefix":"10.1200","volume":"27","author":[{"given":"Jean-Marc","family":"Classe","sequence":"first","affiliation":[{"name":"From the Departments of Surgery and Statistics, Comprehensive Cancer Center, Centre Ren\u00e9 Gauducheau, Nantes, Saint Herblain; Surgical Department, Comprehensive Cancer Center, Centre L\u00e9on B\u00e9rard, Lyon; Gynecological Department, University Hospital, Rennes; Department of Pathology, University Hospital, Nantes; Gynecological Department, University Hospital, Brest; Gynecological Department, University Hospital, Tours; and the Department of Surgery, Comprehensive Cancer Center, Centre Oscar Lambret, Lille,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Bordes","sequence":"additional","affiliation":[{"name":"From the Departments of Surgery and Statistics, Comprehensive Cancer Center, Centre Ren\u00e9 Gauducheau, Nantes, Saint Herblain; Surgical Department, Comprehensive Cancer Center, Centre L\u00e9on B\u00e9rard, Lyon; Gynecological Department, University Hospital, Rennes; Department of Pathology, University Hospital, Nantes; Gynecological Department, University Hospital, Brest; Gynecological Department, University Hospital, Tours; and the Department of Surgery, Comprehensive Cancer Center, Centre Oscar Lambret, 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