{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:11:39Z","timestamp":1791123099486,"version":"4.1.0"},"reference-count":56,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,5,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Increased reactive oxygen species may exhaust the antioxidant capability of human defense systems, leading to oxidative stress and cancer development. Urinary F2-isoprostanes, secondary end products of lipid peroxidation, are more accurate markers of oxidative stress than other available biomarkers. No prospective study has investigated whether levels of 15-F<jats:sub>2t<\/jats:sub>-isoprostane (15-F<jats:sub>2t<\/jats:sub>-IsoP) and its metabolite 2,3-dinor-5,6-dihydro-15-F<jats:sub>2t<\/jats:sub>-IsoP (15-F<jats:sub>2t<\/jats:sub>-IsoPM) are related to breast cancer risk. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We conducted a nested case-control study within the Shanghai Women's Health Study, a population-based cohort study of 74,942 Chinese women between 40 and 70 years of age. Prediagnostic urinary 15-F<jats:sub>2t<\/jats:sub>-IsoP and 15-F<jats:sub>2t<\/jats:sub>-IsoPM were measured by gas chromatography mass spectrometry for 436 breast cancer cases and 852 individually matched controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Urinary excretion of isoprostanes was not significantly different between cases and controls. However, among overweight women, levels of isoprostanes were positively associated with breast cancer risk, which became stronger with increasing body mass index (BMI). Among women with a BMI \u2265 29, the odds ratio (OR) increased to 10.27 (95% CI, 2.41 to 43.80) for the highest compared with the lowest tertile of 15-F<jats:sub>2t<\/jats:sub>-IsoPM (P for trend = .003; P for interaction = .0004). In contrast, 15-F<jats:sub>2t<\/jats:sub>-IsoP and 15-F<jats:sub>2t<\/jats:sub>-IsoPM were inversely associated with breast cancer risk among nonoverweight women. Among women with a BMI \u2264 23, breast cancer risk was reduced with increasing 15-F<jats:sub>2t<\/jats:sub>-IsoP levels in a dose-response manner (P for trend = .006), with an OR of 0.46 (95% CI, 0.26 to 0.80) for the highest tertile versus the lowest (P for interaction = .006). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our results suggest that the role of oxidative stress in breast cancer development may depend on adiposity. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.19.7970","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:50:21Z","timestamp":1240275021000},"page":"2482-2488","source":"Crossref","is-referenced-by-count":92,"title":["Oxidative Stress, Obesity, and Breast Cancer Risk: Results From the Shanghai Women's Health Study"],"prefix":"10.1200","volume":"27","author":[{"given":"Qi","family":"Dai","sequence":"first","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and 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Medicine and Pharmacology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyin","family":"Cai","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Pharmacology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, TN; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; and Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Wen","sequence":"additional","affiliation":[{"name":"From the 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