{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:05:14Z","timestamp":1792101914802,"version":"4.4.0"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To report on the outcomes of a phase I study of stereotactic body radiotherapy (SBRT) for treatment of liver metastases. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with liver metastases that were inoperable or medically unsuitable for resection, and who were not candidates for standard therapies, were eligible for this phase I study of individualized SBRT. Individualized radiation doses were chosen to maintain the same nominal risk of radiation-induced liver disease (RILD) for three estimated risk levels (5%, 10%, and 20%). Additional patients were treated at the maximal study dose (MSD) in an expanded cohort. Median SBRT dose was 41.8 Gy (range, 27.7 to 60 Gy) in six fractions over 2 weeks. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Sixty-eight patients with inoperable colorectal (n = 40), breast (n = 12), or other (n = 16) liver metastases were treated. Median tumor volume was 75.2 mL (range, 1.19 to 3,090 mL). The highest RILD risk level investigated was safe, with no dose-limiting toxicity. Two grade 3 liver enzyme changes occurred, but no RILD or other grade 3 to 5 liver toxicity was seen, for a low estimated risk of serious liver toxicity (95% CI, 0 to 5.3%). Six (9%) acute grade 3 toxicities (two gastritis, two nausea, lethargy, and thrombocytopenia) and one (1%) grade 4 toxicity (thrombocytopenia) were seen. The 1-year local control rate was 71% (95 CI, 58% to 85%). The median overall survival was 17.6 months (95% CI, 10.4 to 38.1 months). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Individualized six-fraction liver metastases SBRT is safe, with sustained local control observed in the majority of patients. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.20.0600","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T02:11:18Z","timestamp":1236046278000},"page":"1585-1591","source":"Crossref","is-referenced-by-count":406,"title":["Phase I Study of Individualized Stereotactic Body Radiotherapy of Liver Metastases"],"prefix":"10.1200","volume":"27","author":[{"given":"Mark T.","family":"Lee","sequence":"first","affiliation":[{"name":"From the Radiation Medicine Program, Departments of Biostatistics and Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, 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