{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:52:39Z","timestamp":1787737959524,"version":"build-2784847793"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,10,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the prevalence of arthralgia in breast cancer patients taking aromatase inhibitors (AIs) and perform a detailed rheumatologic assessment including autoimmune serology, musculoskeletal sonography, and electromyography (EMG) in these patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Postmenopausal patients with stage I to III breast cancer who were taking adjuvant AIs were enrolled (n = 92). Patients who were not receiving hormone treatment were included as a control group (n = 28). Musculoskeletal sonography and EMG were applied to the patients and the controls along with markers of autoimmunity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Thirty patients (32.6%) reported to have AI-related new-onset or worsening arthralgia. The most commonly affected joints were knee (70%), wrist (70%), and small joints of the hand (63%). Patients taking AIs had increased tendon thicknesses compared with those who never received AIs (P &lt; .001). Patients with AI-related arthralgia had higher rates of effusion in hand joints\/tendons than those without arthralgia (P = .033). More patients with AI-related arthralgia had EMG findings consistent with carpal tunnel syndrome (CTS) than those without arthralgia (P = .024). No significant difference was observed in erythrocyte sedimentation rates, C-reactive protein, antinuclear antibody, antidouble stranded DNA antibody, rheumatoid factor, or anticyclic citrullinated peptide levels between patients and controls or between those with and without arthralgia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Patients with AI-related arthralgia often show tenosynovial changes suggesting tenosynovitis, exerting local problems but lacking a systemic inflammatory component. Our finding of increased CTS frequency also supports this hypothesis. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.20.5435","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T01:34:54Z","timestamp":1252978494000},"page":"4955-4960","source":"Crossref","is-referenced-by-count":65,"title":["Sonographic and Electrodiagnostic Evaluations in Patients With Aromatase Inhibitor\u2013Related Arthralgia"],"prefix":"10.1200","volume":"27","author":[{"given":"Omer","family":"Dizdar","sequence":"first","affiliation":[{"name":"From the Department of Medical Oncology, Hacettepe University Institute of Oncology; and the Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"\u00d6z\u00e7akar","sequence":"additional","affiliation":[{"name":"From the Department of Medical Oncology, Hacettepe University Institute of Oncology; and the Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Ankara, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fevziye \u00dcnsal","family":"Malas","sequence":"additional","affiliation":[{"name":"From the Department of Medical Oncology, Hacettepe University Institute of Oncology; 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