{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:15:30Z","timestamp":1790864130641,"version":"4.1.0"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the prognostic importance of the meningioma 1 (MN1) gene expression levels in the context of other predictive molecular markers, and to derive MN1 associated gene\u2013 and microRNA\u2013expression profiles in cytogenetically normal acute myeloid leukemia (CN-AML). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> MN1 expression was measured in 119 untreated primary CN-AML adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. Patients were also tested for FLT3, NPM1, CEBPA, and WT1 mutations, MLL partial tandem duplications, and BAALC and ERG expression. Gene- and microRNA-expression profiles were attained by performing genome-wide microarray assays. Patients were intensively treated on two first-line Cancer and Leukemia Group B clinical trials. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Higher MN1 expression associated with NPM1 wild-type (P &lt; .001), increased BAALC expression (P = .004), and less extramedullary involvement (P = .01). In multivariable analyses, higher MN1 expression associated with a lower complete remission rate (P = .005) after adjustment for WBC; shorter disease-free survival (P = .01) after adjustment for WT1 mutations, FLT3 internal tandem duplications (FLT3-ITD), and high ERG expression; and shorter survival (P = .04) after adjustment for WT1 and NPM1 mutations, FLT3-ITD, and WBC. Gene- and microRNA-expression profiles suggested that high MN1 expressers share features with high BAALC expressers and patients with wild-type NPM1. Higher MN1 expression also appears to be associated with genes and microRNAs that are active in aberrant macrophage\/monocytoid function and differentiation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> MN1 expression independently predicts outcome in CN-AML patients. The MN1 gene- and microRNA-expression signatures suggest biologic features that could be exploited as therapeutic targets. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.20.6110","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T01:47:03Z","timestamp":1242697623000},"page":"3198-3204","source":"Crossref","is-referenced-by-count":132,"title":["Prognostic Importance of <i>MN1<\/i> Transcript Levels, and Biologic Insights From <i>MN1<\/i>-Associated Gene and MicroRNA Expression Signatures in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study"],"prefix":"10.1200","volume":"27","author":[{"given":"Christian","family":"Langer","sequence":"first","affiliation":[{"name":"From the Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham; Wake Forest University School of Medicine, Winston-Salem, NC; Washington University School of Medicine, Siteman Cancer Center, St Louis, MO; University of Alabama at Birmingham, Birmingham, AL; North Shore University Hospital, Manhasset, NY; University of Chicago,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham; Wake Forest University School of Medicine, Winston-Salem, NC; Washington University School of Medicine, Siteman Cancer Center, St Louis, MO; University of Alabama at Birmingham, Birmingham, AL; North Shore University Hospital, Manhasset, NY; University of Chicago,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsi B.","family":"Holland","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham; Wake Forest University School of Medicine, Winston-Salem, NC; Washington University School of Medicine, Siteman Cancer Center, St Louis, MO; University of Alabama at Birmingham, Birmingham, AL; North Shore University Hospital, Manhasset, NY; University of Chicago,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Radmacher","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham; Wake Forest University School of Medicine, Winston-Salem, NC; Washington University School of Medicine, Siteman Cancer Center, St Louis, MO; University of Alabama at Birmingham, Birmingham, AL; North Shore University Hospital, Manhasset, NY; University of Chicago,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Maharry","sequence":"additional","affiliation":[{"name":"From the Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham; Wake Forest University School of Medicine, Winston-Salem, NC; Washington University School of Medicine, Siteman Cancer Center, St Louis, MO; University of Alabama at Birmingham, Birmingham, AL; North Shore University Hospital, Manhasset, NY; University of 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