{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:18:24Z","timestamp":1792919904445,"version":"4.5.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,7,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Disease dissemination to the bone marrow is detected at diagnosis in approximately 15% of children with T-cell lymphoblastic lymphoma (T-LL). It is unclear whether the remaining patients have submicroscopic systemic disease and, if so, what is the clinical significance of this finding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Using a flow cytometric method that can detect one T-LL cell among 10,000 normal cells, we examined bone marrow and peripheral-blood samples collected from 99 children with T-LL at diagnosis, as well as blood samples collected from 42 patients during treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 71 (71.7%) of the 99 marrow samples obtained at diagnosis, T-LL cells represented 0.01% to 31.6% (median, 0.22%) of mononuclear cells; 57 of the 71 T-LL\u2013positive samples were from patients with stage II\/III disease. Results of studies in bilateral marrow aspirates were highly concordant. Two-year event-free survival (EFS) was 68.1% \u00b1 11.1% (SE) for patients with \u2265 1% T-LL cells in bone marrow versus 90.7% \u00b1 4.4% for those with lower levels of marrow involvement (P = .031); EFS for patients with \u2265 5% lymphoblasts was 51.9% \u00b1 18.0% (P = .009). T-LL cells were as prevalent in blood as in marrow; monitoring residual T-LL cells in blood during remission induction therapy identified patients with slower disease clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than two thirds of children with T-LL have disseminated disease at diagnosis, a proportion much higher than previously demonstrated. Measurements of disease dissemination at diagnosis might provide useful prognostic information, which can be further refined by monitoring response to therapy through blood testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2008.21.1318","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T21:56:20Z","timestamp":1245707780000},"page":"3533-3539","source":"Crossref","is-referenced-by-count":99,"title":["Minimal Disseminated Disease in Childhood T-Cell Lymphoblastic Lymphoma: A Report From the Children's Oncology Group"],"prefix":"10.1200","volume":"27","author":[{"given":"Elaine","family":"Coustan-Smith","sequence":"first","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Sandlund","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minnie","family":"Abromowitch","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, UT; Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL; and Section of Hematology\/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Campana","sequence":"additional","affiliation":[{"name":"From the Departments of Oncology and Pathology, St Jude Children's Research Hospital, and University of Tennessee Health Center, Memphis, TN; 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