{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:56:37Z","timestamp":1762541797792},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"Purpose<\/jats:title> For nearly two decades, multiple retrospective reports, small prospective studies, and meta-analyses have arrived at conflicting results regarding the value of timing surgical intervention for breast cancer on the basis of menstrual cycle phase. We present the results of a multi\u2013cooperative group, prospective, observational trial of menstrual cycle phase and outcome after breast cancer surgery, led by the North Central Cancer Treatment Group (NCCTG) in collaboration with the National Surgical Adjuvant Breast and Bowel Project (NSABP) and the International Breast Cancer Study Group (IBCSG). <\/jats:p><\/jats:sec>Patients and Methods<\/jats:title> Premenopausal women age 18 to 55 years, who were interviewed for menstrual history and who were surgically treated for stages I to II breast cancer, had serum drawn within 1 day of surgery for estradiol, progesterone, and luteinizing hormone levels. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. Disease-free survival (DFS) and overall survival (OS) rates were determined by Kaplan-Meier method and were compared by using the log-rank test and Cox proportional hazard modeling. <\/jats:p><\/jats:sec>Results<\/jats:title> Of 1,118 women initially enrolled, 834 women comprised the study cohort: 230 (28%) in luteal phase; 363 (44%) in follicular phase; and 241 grouped as other. During a median follow-up of 6.6 years, and in analysis that accounted for nodal disease, estrogen receptor status, adjuvant radiation therapy or chemotherapy, neither DFS nor OS differed with respect to menstrual phase. The 5-year DFS rates were 82.7%, 82.1%, and 79.2% for follicular, luteal, or other phases, respectively. Corresponding OS survival rates were 91.9%, 92.2%, and 91.8%, respectively. <\/jats:p><\/jats:sec>Conclusion<\/jats:title> When menstrual cycle phases were strictly defined, neither DFS nor OS differed between women who underwent surgery during the follicular phase versus the luteal phase. Nearly 30% of the patients did not meet criteria for either follicular- or luteal-phase categories. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2008.21.3603","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T00:36:01Z","timestamp":1243902961000},"page":"3620-3626","source":"Crossref","is-referenced-by-count":19,"title":["Menstrual Cycle and Surgical Treatment of Breast Cancer: Findings From the NCCTG N9431 Study"],"prefix":"10.1200","volume":"27","author":[{"given":"Clive S.","family":"Grant","sequence":"first","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Ingle","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera J.","family":"Suman","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Dumesic","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Lawrence","family":"Wickerham","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Gelber","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Flynn","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna M.","family":"Weir","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Intra","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne O.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith A.","family":"Perez","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; North Central Cancer Treatment Group, Reproductive Medicine and Infertility Associates, Woodbury, MN; North Central Cancer Treatment Group, Allegheny Cancer Center, Pittsburgh, PA; National Surgical Adjuvant Breast and Bowel Project, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; National Surgical Adjuvant Breast and Bowel Project, International..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn C.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"From the Division of General Surgery, Division of Medical Oncology, Cancer Center Statistics, Mayo Clinic, Rochester, MN; 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