{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:44:13Z","timestamp":1790174653299,"version":"4.1.0"},"reference-count":111,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,10,10]]},"abstract":"<jats:p> Tumor-associated neoangiogenesis has recently become a suitable target for antineoplastic drug development. In this overview, we discuss specific drug-associated hemostatic complications, the already known pathogenetic mechanisms involved, and the effect of varying antithrombotic strategies. Multiple agents with angiogenic inhibitory capacity (thalidomide, lenalidomide, bevacizumab, sunitinib, sorafenib, and sirolimus) have obtained US Food and Drug Administration approval, and many others have entered clinical trials. Arterial and venous thromboembolism and hemorrhage have emerged as significant toxicities associated with the use of angiogenesis inhibitors. We present a detailed analysis of the literature on thrombotic complication of antiangiogenic drugs. Close attention to hemostatic complications during antiangiogenic treatment is warranted. Further studies are required to better understand the pathophysiologic mechanisms involved and to define a safe prophylactic strategy. <\/jats:p>","DOI":"10.1200\/jco.2009.22.3875","type":"journal-article","created":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T02:05:28Z","timestamp":1251165928000},"page":"4865-4873","source":"Crossref","is-referenced-by-count":158,"title":["Thrombotic Events in Patients With Cancer Receiving Antiangiogenesis Agents"],"prefix":"10.1200","volume":"27","author":[{"given":"Maurizio","family":"Zangari","sequence":"first","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"Fink","sequence":"additional","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Elice","sequence":"additional","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghuang","family":"Zhan","sequence":"additional","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy M.","family":"Adcock","sequence":"additional","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J.","family":"Tricot","sequence":"additional","affiliation":[{"name":"From the University of Utah, Division of Hematology, Blood\/Marrow Transplant and Myeloma Program, Salt Lake City, UT; Nevada Cancer Institute, Laboratory Medicine, Las Vegas, NV; Esoterix, Aurora, CO; and St Bortolo Hospital, Vicenza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.11.019"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.57.121304.131306"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0150-0"},{"key":"B4","first-page":"37","volume":"4","author":"Wu HC","year":"2008","journal-title":"J Cancer Mol"},{"key":"B5","first-page":"1346","volume":"21","author":"Sato M","year":"2007","journal-title":"Oncology (Williston Park)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.10.1701"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1150"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.01.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.0887"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011132808904"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05078.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070594"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070596"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.066"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.656"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm086"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl017"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1571"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065044"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.715"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210153271604"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613051"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1159\/000046583"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.3_suppl.58S"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920901)70:5<1194::AID-CNCR2820700528>3.0.CO;2-E"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-822969"},{"key":"B27","first-page":"6966","volume":"62","author":"Palumbo JS","year":"2002","journal-title":"Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2272"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2008.077"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2350"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-01-0054"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6853"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2005.10.009"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0335"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10847"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.074"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0154"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.052"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200204000-00003"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00083.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00393.x"},{"key":"B43","first-page":"787","volume":"100","author":"Weber D","year":"2002","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0891-6"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06208.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.4.1271"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-8-199904200-00004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(07)70130-5"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn263"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1338"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7933.2003.00573.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12522"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.06.013"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07321.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1159\/000088481"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.81.908"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.022"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1159\/000073281"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199606000-00011"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.9043"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.00.232"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.6305"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3212"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-6-713"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.098"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2309"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.9847"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0404"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0221-3"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0157"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0871-5"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.6.1657"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.046"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69446-4"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.5415"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.8637"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9303"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6723"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.3441"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.3342"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0981-3"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-01-0041"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.170"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-006-5934-5"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060655"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.03.005"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.034"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/S1533-0028(11)70162-1"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2798"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00331.x"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.2174\/156800908786733513"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.025"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403533"},{"key":"B96","first-page":"826","volume":"89","author":"Cavo M","year":"2004","journal-title":"Haematologica"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.4065\/80.12.1568"},{"key":"B98","first-page":"429","volume":"22","author":"Salimichokami M","year":"2003","journal-title":"Proc Am Soc Clin Oncol"},{"key":"B99","volume-title":"Presented at the 13th Congress of the European Hematology Association","author":"Palumbo A"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.0221"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.139"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200403"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68338-4"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2817"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0561-1"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3463"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl313"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.23.16_suppl.3554"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.22.14_suppl.3528"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00133.2005"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707330"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.22.3875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:20:06Z","timestamp":1653520806000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.22.3875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,10]]},"references-count":111,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2009,10,10]]}},"alternative-id":["10.1200\/JCO.2009.22.3875"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.22.3875","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,10]]}}}