{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:16:36Z","timestamp":1791141396895,"version":"4.1.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,5,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The primary objective was to determine the efficacy of a newly designed preoperative chemotherapy regimen in an attempt to improve the cure rate of children with high-risk hepatoblastoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>High risk was defined as follows: tumor in all liver sections (ie, Pretreatment Extension IV [PRETEXT-IV]), or vascular invasion (portal vein [P+], three hepatic veins [V+]), or intra-abdominal extrahepatic extension (E+), or metastatic disease, or \u03b1-fetoprotein less than 100 ng\/mL at diagnosis. Patients were treated with alternating cycles of cisplatin and carboplatin plus doxorubicin (preoperatively, n = 7; postoperatively, n = 3) and delayed tumor resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 151 patients (150 evaluable for response) 118 (78.7%) achieved a partial response to chemotherapy. Complete resection of the liver tumor could be achieved in 115 patients (76.2%) either by partial hepatectomy (55.6%) or by liver transplantation (20.6%). In 106 children (70.2%), complete resection of all tumor lesions (including metastases) was achieved. Among the patients with initial lung metastases, 52.2% achieved complete remission of the lung lesions with chemotherapy alone. In half of the patients with initial PRETEXT-IV tumor as the only high-risk feature, the tumor could be completely resected with partial hepatectomy. Event-free (EFS) and overall survival (OS) estimates at 3 years were 65% (95% CI, 57% to 73%) and 69% (95% CI, 62% to 77%) for the whole group. EFS and OS for all patients with PRETEXT-IV tumor were 68% and 69%, respectively, and they were 56% and 62%, respectively, for patients with metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The applied treatment rendered a great proportion of tumors resectable, and, in comparison with previously published results, led to an improved survival in patients with high-risk hepatoblastoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.22.4857","type":"journal-article","created":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T22:25:37Z","timestamp":1271802337000},"page":"2584-2590","source":"Crossref","is-referenced-by-count":280,"title":["Successful Treatment of Childhood High-Risk Hepatoblastoma With Dose-Intensive Multiagent Chemotherapy and Surgery: Final Results of the SIOPEL-3HR Study"],"prefix":"10.1200","volume":"28","author":[{"given":"J\u00f3zsef","family":"Zs\u00edros","sequence":"first","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Maibach","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shafford","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugieres","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Brock","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czauderna","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Roebuck","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Childs","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Laithier","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Bernard","family":"Otte","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"de Camargo","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"MacKinlay","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Scopinaro","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aronson","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Plaschkes","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Perilongo","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatric Oncology and of Pediatric Surgery, Emma Children's Hospital\/Academic Medical Centre, Amsterdam, the Netherlands; International Breast Cancer Study Group, Coordinating Center; and Department of Surgical Pathology, Institute of Pathology; and Department of Surgery, University Children's Hospital, Bern, Switzerland; Children's Cancer and Leukaemia Group (CCLG), Data Centre, Leicester; and Departments of Haematology and Oncology and of Radiology, Great Ormond St Hospital for..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.22.3819"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820901)50:5<821::AID-CNCR2820500502>3.0.CO;2-K"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00049-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00018-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.14.2665"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10632"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.12.2167"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90762-9"},{"key":"B9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-2008-1046615","volume":"206","author":"von Schweinitz D","year":"1994","journal-title":"Klin Padiatr"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.400"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1043805"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10376"},{"key":"B13","first-page":"562","volume":"17","author":"Otte JB","year":"2004","journal-title":"Transpl Int"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00354.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.06.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.11.022"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-005-0029-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.145"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950190415"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00074-5"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001015)89:8<1845::AID-CNCR27>3.0.CO;2-D"},{"key":"B23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-2003-39375","volume":"215","author":"Haberle B","year":"2003","journal-title":"Klin Padiatr"},{"key":"B24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00383-002-0906-0","volume":"19","author":"Matsunaga T","year":"2003","journal-title":"Pediatr Surg Int"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.6013"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.22.4857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T19:56:53Z","timestamp":1653508613000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.22.4857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,20]]},"references-count":25,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2010,5,20]]}},"alternative-id":["10.1200\/JCO.2009.22.4857"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.22.4857","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,20]]}}}