{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:42:21Z","timestamp":1790739741807,"version":"4.1.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,2,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>First-line treatment for patients with newly diagnosed follicular lymphoma (FL) still remains debated, even in the rituximab-based combination therapy era. Few studies have addressed the question whether complete remission (CR) translates into better survival. The aim of this study was to assess the long-term follow-up of prospectively treated patients with FL and the potential correlation between response quality to first-line treatment and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Data from 536 patients with FL with low (n = 193) or high (n = 343) tumor burden enrolled from October 1986 to May 1995 in the French and Belgian GELF86 studies were analyzed. Data from these trials have been previously reported for low\u2013tumor burden and high\u2013tumor burden patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow-up was 14.9 years, and median OS was 9.8 years. Treated patients who achieved a complete response (CR; n = 194; 45%) had a significant longer OS than those only reaching a partial response (PR; n = 168; 39%) throughout treatment (hazard ratio [HR], 0.55; 95% CI, 0.42 to 0.72; P &lt; .001) in an univariate time-dependent Cox model. Similar findings were found when response to treatment (CR v PR) was adjusted for potentially confounding factors in a multivariate model (HR, 0.53; 95% CI, 0.38 to 0.73; P &lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data provide a long follow-up of these patients' cohorts and indicate that a better response to first-line treatment translates into an improved survival for patients with FL. Therefore, response-adapted therapy aiming to achieve a CR should be considered as first-line treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.22.7819","type":"journal-article","created":{"date-parts":[[2009,12,21]],"date-time":"2009-12-21T21:42:51Z","timestamp":1261431771000},"page":"822-829","source":"Crossref","is-referenced-by-count":61,"title":["Long-Term Follow-Up of Patients With Newly Diagnosed Follicular Lymphoma in the Prerituximab Era: Effect of Response Quality on Survival\u2014A Study From the Groupe d'Etude des Lymphomes de l'Adulte"],"prefix":"10.1200","volume":"28","author":[{"given":"Emmanuel","family":"Bachy","sequence":"first","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Brice","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Delarue","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Brousse","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Haioun","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Le Gouill","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Delmer","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Bordessoule","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Tilly","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Corront","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Allard","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Foussard","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bosly","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Coiffier","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; 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CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"From the Hospices Civils de Lyon and Universit\u00e9 Claude Bernard Lyon 1, Pierre B\u00e9nite; UMR CNRS 5239, Lyon; Centre Hospitalier Universitaire (CHU) Saint Louis; CHU Necker, Paris; CHU Henri Mondor, Creteil; CHU Nantes and L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR892; CHU de Reims; CHU de Limoges, Centre Henri Becquerel and University of Rouen; CH d'Annecy; CH de Meaux; CHU d'Angers; Centre Victor Hugo, Le Mans, France; and the Centre Mont-Godinne, Yvoir, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","first-page":"75","volume":"20","author":"Horning SJ","year":"1993","journal-title":"Semin Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3696"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1674"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22649"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.503"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"B7","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood-2005-01-0016","volume":"106","author":"Hiddemann W","year":"2005","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153189"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.125"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6112.533"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_2.S67"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.07.170"},{"key":"B14","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/cncr.22093","volume":"107","author":"Nickenig C","year":"2006","journal-title":"Cancer"},{"key":"B15","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1182\/blood-2006-03-013193","volume":"108","author":"Sebban C","year":"2006","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.7952"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311253292203"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.7.2332"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1110"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"B22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox DR","year":"1972","journal-title":"J Royal Stat Soc Series B"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1000"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2499"},{"key":"B26","first-page":"783","volume":"95","author":"Federico M","year":"2000","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5358"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0982"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3920"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.146"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.22.7819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:12:29Z","timestamp":1739470349000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.22.7819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,2,10]]}},"alternative-id":["10.1200\/JCO.2009.22.7819"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.22.7819","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1667956.1171054","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,10]]}}}