{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:31:41Z","timestamp":1789443101415,"version":"build-2803163510"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,11,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This multicenter, prospective, randomized controlled trial compared the efficacy and toxicity of two chemotherapy regimens in advanced Hodgkin's lymphoma (HL): the weekly alternating Stanford V and the standard, twice-weekly regimen of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients had stage IIB, III, or IV disease or had stages I to IIA disease with bulky disease or other adverse features. Radiotherapy was administered in both arms to sites of previous bulk (&gt; 5 cm) and to splenic deposits, although this was omitted in the latter part of the trial for patients achieving complete remission (CR) in the ABVD arm. A total of 520 patients were randomly assigned and were assessed for the primary outcome measure of progression-free survival (PFS). Five hundred patients received protocol treatment, and radiotherapy was administered to 73% in the Stanford V arm and to 53% in the ABVD arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall response rates after completion of all treatment were 91% for Stanford V and 92% for ABVD. During a median follow-up of 4.3 years, there was no evidence of a difference in projected 5-year PFS and overall survival (OS) rates (76% and 90%, respectively, for ABVD; 74% and 92%, respectively, for Stanford V). More pulmonary toxicity was reported for ABVD, whereas other toxicities were more frequent with Stanford V.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a large, randomized trial, the efficacies of Stanford V and ABVD were comparable when given in combination with appropriate radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.23.3239","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T22:19:23Z","timestamp":1252448363000},"page":"5390-5396","source":"Crossref","is-referenced-by-count":150,"title":["Randomized Comparison of the Stanford V Regimen and ABVD in the Treatment of Advanced Hodgkin's Lymphoma: United Kingdom National Cancer Research Institute Lymphoma Group Study ISRCTN 64141244"],"prefix":"10.1200","volume":"27","author":[{"given":"Peter J.","family":"Hoskin","sequence":"first","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lowry","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Horwich","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Jack","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Mead","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry W.","family":"Hancock","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Qian","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Patrick","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilyana","family":"Popova","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pettitt","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cunningham","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Pettengell","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sweetenham","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Linch","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Mount Vernon Cancer Centre, Department of Clinical Oncology; Lymphoma Trials Office, Cancer Research United Kingdom and University College London Cancer Trials Centre; Department of Radiotherapy, Institute of Cancer Research and Royal Marsden Hospital; Medical Research Council Cancer Trials Unit; St George's Hospital Medical School; Royal Marsden Hospital; and University College London Cancer Institute, London; St James' Institute of Oncology, Haematological Malignancy Diagnostic Service, Leeds;..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.1.27"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200205023461821"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.12.086"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2151"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211193272102"},{"key":"B6","doi-asserted-by":"crossref","first-page":"B89","DOI":"10.1007\/PL00022800","volume":"80","author":"Hasenclever D","year":"2001","journal-title":"Ann Hematol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008282020341"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.107"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.5.1080"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2002.20.3.630"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.5.972"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.907"},{"key":"B13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1182\/blood.V112.11.2602.2602","volume":"112","author":"Chisesi T","year":"2008","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811193392104"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/56458296"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022628"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"B18","first-page":"11","volume":"112","author":"Johnson PWM","year":"2008","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.12.3810"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.23.16_suppl.6507"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.8506"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.0910"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.23.3239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T13:00:34Z","timestamp":1685106034000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.23.3239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,10]]},"references-count":22,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2009,11,10]]}},"alternative-id":["10.1200\/JCO.2009.23.3239"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.23.3239","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1380961.853061","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,10]]}}}