{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:24:46Z","timestamp":1791343486499,"version":"4.3.1"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In a phase III randomized trial, azacitidine significantly prolonged overall survival (OS) compared with conventional care regimens (CCRs) in patients with intermediate-2\u2013 and high-risk myelodysplastic syndromes. Approximately one third of these patients were classified as having acute myeloid leukemia (AML) under current WHO criteria. This analysis compared the effects of azacitidine versus CCR on OS in this subgroup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients were randomly assigned to receive subcutaneous azacitidine 75 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/d or CCR (best supportive care [BSC] only, low-dose cytarabine (LDAC), or intensive chemotherapy [IC]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 113 elderly patients (median age, 70 years) randomly assigned to receive azacitidine (n = 55) or CCR (n = 58; 47% BSC, 34% LDAC, 19% IC), 86% were considered unfit for IC. At a median follow-up of 20.1 months, median OS for azacitidine-treated patients was 24.5 months compared with 16.0 months for CCR-treated patients (hazard ratio = 0.47; 95% CI, 0.28 to 0.79; P = .005), and 2-year OS rates were 50% and 16%, respectively (P = .001). Two-year OS rates were higher with azacitidine versus CCR in patients considered unfit for IC (P = .0003). Azacitidine was associated with fewer total days in hospital (P &lt; .0001) than CCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In older adult patients with low marrow blast count (20% to 30%) WHO-defined AML, azacitidine significantly prolongs OS and significantly improves several patient morbidity measures compared with CCR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.23.8329","type":"journal-article","created":{"date-parts":[[2009,12,21]],"date-time":"2009-12-21T21:42:51Z","timestamp":1261431771000},"page":"562-569","source":"Crossref","is-referenced-by-count":841,"title":["Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia"],"prefix":"10.1200","volume":"28","author":[{"given":"Pierre","family":"Fenaux","sequence":"first","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam J.","family":"Mufti","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hellstr\u00f6m-Lindberg","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Santini","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gattermann","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Sanz","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"List","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gore","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Seymour","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Backstrom","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McKenzie","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Beach","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis R.","family":"Silverman","sequence":"additional","affiliation":[{"name":"From the Avicenne, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Universit\u00e9 Paris XIII, Bobigny; H\u00f4pital Saint-Louis, AP-HP, Universit\u00e9 Paris 7, Paris, France; King's College Hospital, London, United Kingdom; Karolinska University Hospital (Huddinge), Stockholm, Sweden; Azienda Ospedaliera Universitaria Careggi, Florence, Italy; Universit\u00e4tsklinikum D\u00fcsseldorf, D\u00fcsseldorf, Germany; Hospital Universitario La Fe, Valencia, Spain; Peter MacCallum Cancer Centre and University of Melbourne, Melbourne,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31818a6c93"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V108.11.1973.1973"},{"key":"B3","first-page":"S975","volume":"6","author":"Williams JP","year":"2000","journal-title":"Am J Manag Care"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.14.1597"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411407"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3724"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.03.002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2008.04.013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21723"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22779"},{"key":"B13","first-page":"1513","volume":"91","author":"Deschler B","year":"2006","journal-title":"Haematologica"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.12.4343"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-124602"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-198093"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.2.272"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0354"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-069666"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70003-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb08475.x"},{"key":"B22","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Arber DA","year":"2008","edition":"4"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1199"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-2570(03)00031-5"},{"key":"B26","first-page":"1286","volume":"87","author":"Alessandrino EP","year":"2002","journal-title":"Haematologica"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.03907.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.036"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2079"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.4346"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(00)00088-6"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.3.1100"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00220-5"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.2969"},{"key":"B35","first-page":"366","volume":"71","author":"Fukuhara T","year":"2000","journal-title":"Int J Hematol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb02982.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035725"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.001263"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000098957"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.1.372"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1309\/EM7KCQR4GLMHRCX4"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2486"},{"key":"B43","first-page":"2952","volume":"90","author":"L\u00f6wenberg B","year":"1997","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1686"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22496"},{"key":"B46","first-page":"126","volume":"14","author":"Cheson BD","year":"1987","journal-title":"Semin Oncol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/BF01738471"},{"key":"B48","volume":"108","author":"Burnett AK","year":"2006","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.0961"},{"key":"B50","volume":"112","author":"Erba HP","year":"2008","journal-title":"Blood"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.23.8329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:34:00Z","timestamp":1653510840000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.23.8329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,2,1]]}},"alternative-id":["10.1200\/JCO.2009.23.8329"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.23.8329","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2362957.1991055","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,1]]}}}