{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:02:12Z","timestamp":1793073732223,"version":"4.5.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2009,12,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This multi-institutional registry study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for diffuse malignant peritoneal mesothelioma (DMPM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A multi-institutional data registry that included 405 patients with DMPM treated by a uniform approach that used CRS and HIPEC was established. The primary end point was overall survival. The secondary end point was evaluation of prognostic variables for overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Follow-up was complete in 401 patients (99%). The median follow-up period for the patients who were alive was 33 months (range, 1 to 235 months). The mean age was 50 years (standard deviation [SD], 14 years). Three hundred eighteen patients (79%) had epithelial tumors. Twenty-five patients (6%) had positive lymph nodes. The mean peritoneal cancer index was 20. One hundred eighty-seven patients (46%) had complete or near-complete cytoreduction. Three hundred seventy-two patients (92%) received HIPEC. One hundred twenty-seven patients (31%) had grades 3 to 4 complications. Nine patients (2%) died perioperatively. The mean length of hospital stay was 22 days (SD, 15 days). The overall median survival was 53 months (1 to 235 months), and 3- and 5-year survival rates were 60% and 47%, respectively. Four prognostic factors were independently associated with improved survival in the multivariate analysis: epithelial subtype (P &lt; .001), absence of lymph node metastasis (P &lt; .001), completeness of cytoreduction scores of CC-0 or CC-1 (P &lt; .001), and HIPEC (P = .002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The data suggest that CRS combined with HIPEC achieved prolonged survival in selected patients with DMPM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.23.9640","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T22:09:05Z","timestamp":1258409345000},"page":"6237-6242","source":"Crossref","is-referenced-by-count":608,"title":["Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: Multi-Institutional Experience"],"prefix":"10.1200","volume":"27","author":[{"given":"Tristan D.","family":"Yan","sequence":"first","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Deraco","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Baratti","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Kusamura","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Elias","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Glehen","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois N.","family":"Gilly","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Levine","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Shen","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheez","family":"Mohamed","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Moran","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Morris","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; 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National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Sugarbaker","sequence":"additional","affiliation":[{"name":"From the University of New South Wales, Department of Surgery, St George Hospital; and University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney, Australia; National Cancer Institute of Milan, Milan, Italy; Institut Gustave Roussy, Villejuif; and Hospices Civils de Lyon and Unviversit\u00e9 Lyon, Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, France; Wake Forest University, Winston-Salem, NC; North Hampshire Hospital, Basingstoke, United Kingdom; University Medical Center,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","unstructured":"H Battifora, W McCaughey: Tumors of the Serosal Membranes 1994 Washington, DC Armed Forces Institute of Pathology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1179\/oeh.2005.11.3.254"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh025"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/oem.51.12.804"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700120212"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.93.1.159"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.1.147"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921215)70:12<2969::AID-CNCR2820701239>3.0.CO;2-A"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01225271"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.6.507"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s002920050340"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199901)70:1<6::AID-JSO2>3.0.CO;2-X"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00045-0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9169-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-999-0582-6"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.150"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21239"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.03.045"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.05.041"},{"key":"B21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1177\/000313480106701019","volume":"67","author":"Loggie BW","year":"2001","journal-title":"Am Surg"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.05.009"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/030089160308900307"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5377"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00029-2"},{"key":"B28","first-page":"1252","volume":"52","author":"Los G","year":"1992","journal-title":"Cancer Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00370-5"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(91)90389-U"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2868"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.23.9640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T11:36:00Z","timestamp":1685187360000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.23.9640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,20]]},"references-count":31,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2009,12,20]]}},"alternative-id":["10.1200\/JCO.2009.23.9640"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.23.9640","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,20]]}}}