{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:58:27Z","timestamp":1791464307475,"version":"4.3.4"},"reference-count":28,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,5,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To compare the frequency of visceral relapse of BRCA1\/2-deficient ovarian cancer to that of nonhereditary controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> All patients diagnosed in Scotland with epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC) and a germline BRCA1\/2 mutation were identified. Those with previous malignancy were excluded. Each remaining patient who experienced relapse was matched with two nonhereditary controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Seventy-nine patients with EOC\/PPC and germline BRCA1\/2 mutations were identified. Fifteen had inadequate clinical data, two had carcinosarcoma, 27 had previous breast cancer, and 16 were in remission. Of the remaining 19 patients who were BRCA1\/2 deficient, 14 patients (74%) developed visceral metastases compared with six (16%) of 38 patients in the control group. The percentages of liver, lung, and splenic metastases were 53%, 32%, and 32%, respectively, in the patients compared with 5%, 3%, and 5%, respectively, in the controls. When events occurring outside the matched follow-up period were omitted, the percentages of visceral, liver, lung, and splenic metastases were 58%, 42%, 16%, and 32% in the patients compared with 5%, 0%, 0%, and 3% in controls (P &lt; .001, P &lt; .001, P = .066, and P = .011, respectively). In an independent validation set, the corresponding percentages of visceral, liver, lung, and splenic metastases were 63%, 46%, 13%, and 17% in the patients compared with 11%, 4%, 2%, and 2% in controls (P &lt; .001, P &lt; .001, P = .153, and P = .052, respectively). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Although sporadic EOC commonly remains confined to the peritoneum, BRCA1\/2-deficient ovarian cancer frequently metastasizes to viscera. These data extend the ovarian BRCAness phenotype, imply BRCA1\/2-deficient ovarian cancer is biologically distinct, and suggest that patients with visceral metastases should be considered for BRCA1\/2 sequencing. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.25.1082","type":"journal-article","created":{"date-parts":[[2010,4,21]],"date-time":"2010-04-21T02:25:37Z","timestamp":1271816737000},"page":"2505-2511","source":"Crossref","is-referenced-by-count":76,"title":["Increased Incidence of Visceral Metastases in Scottish Patients With BRCA1\/2-Defective Ovarian Cancer: An Extension of the Ovarian BRCAness Phenotype"],"prefix":"10.1200","volume":"28","author":[{"given":"Charlie","family":"Gourley","sequence":"first","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline O.","family":"Michie","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Roxburgh","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Yap","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Harden","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Paul","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Ragupathy","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Todd","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Petty","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Reed","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Hayward","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzyvia","family":"Rye","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.M.","family":"Schellens","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Carmichael","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan B.","family":"Kaye","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Mackean","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Ferguson","sequence":"additional","affiliation":[{"name":"From the University of Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh; Cancer Research United Kingdom Clinical Trials Unit, Beatson West of Scotland Cancer Centre Level 0, Glasgow; ANCHOR Unit and University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen; Cancer Medicine Research Programme, Section of Translational Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-333"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11310"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1703"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.17.2260"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.463"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6905"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611073351901"},{"key":"B9","first-page":"235","volume":"4","author":"Aida H","year":"1998","journal-title":"Clin Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900212"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.5510"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871001)60:7<1561::AID-CNCR2820600725>3.0.CO;2-V"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13054.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2307\/2531743"},{"key":"B15","first-page":"719","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(98)80269-9"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.09.016"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.2.397"},{"key":"B20","first-page":"868","volume":"59","author":"Pharoah PD","year":"1999","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21276"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704243361713"},{"key":"B23","first-page":"1255","volume":"336","author":"Modan B","year":"1997","journal-title":"N Engl J Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn669"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.18_suppl.cra501"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi351"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.10.002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.04.023"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.25.1082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:55:30Z","timestamp":1653522930000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.25.1082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,20]]},"references-count":28,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2010,5,20]]}},"alternative-id":["10.1200\/JCO.2009.25.1082"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.25.1082","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,20]]}}}