{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:36:06Z","timestamp":1790933766700,"version":"4.1.0"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,4,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Inotuzumab ozogamicin (CMC-544) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic agent. This was a phase I study to determine the maximum-tolerated dose (MTD), safety, and preliminary efficacy of inotuzumab ozogamicin in an expanded MTD cohort of patients with relapsed or refractory CD22\n                      <jats:sup>+<\/jats:sup>\n                      B-cell non-Hodgkin's lymphoma (NHL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Inotuzumab ozogamicin was administered intravenously as a single agent once every 3 or 4 weeks at doses ranging from 0.4 to 2.4 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Outcomes included MTD, safety, pharmacokinetics, response, progression-free survival (PFS), and overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-nine patients were enrolled. The MTD was determined to be 1.8 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Common adverse events at the MTD were thrombocytopenia (90%), asthenia (67%), and nausea and neutropenia (51% each). The objective response rate at the end of treatment was 39% for the 79 enrolled patients, 68% for all patients with follicular NHL treated at the MTD, and 15% for all patients with diffuse large B-cell lymphoma treated at the MTD. Median PFS was 317 days (approximately 10.4 months) and 49 days for patients with follicular NHL and diffuse large B-cell lymphoma, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Inotuzumab ozogamicin has demonstrated efficacy against CD22\n                      <jats:sup>+<\/jats:sup>\n                      B-cell NHL, with reversible thrombocytopenia as the main toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.25.1900","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T22:47:58Z","timestamp":1269298078000},"page":"2085-2093","source":"Crossref","is-referenced-by-count":302,"title":["Safety, Pharmacokinetics, and Preliminary Clinical Activity of Inotuzumab Ozogamicin, a Novel Immunoconjugate for the Treatment of B-Cell Non-Hodgkin's Lymphoma: Results of a Phase I Study"],"prefix":"10.1200","volume":"28","author":[{"given":"Anjali","family":"Advani","sequence":"first","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Coiffier","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron S.","family":"Czuczman","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dreyling","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Foran","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gine","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gisselbrecht","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ketterer","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Nasta","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ama","family":"Rohatiner","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo G.H.","family":"Schmidt-Wolf","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schuler","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sierra","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; 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University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; H\u00f4pital Saint Louis, Paris, France; University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane N.","family":"Winter","sequence":"additional","affiliation":[{"name":"From The Cleveland Clinic Taussig Cancer Center, Cleveland, OH; Roswell Park Cancer Institute, Buffalo, NY; University of Alabama at Birmingham, Birmingham, AL; University of Pennsylvania Abramson Cancer Center; Fox Chase Cancer Center, Philadelphia, PA; Feinberg School of Medicine, Northwestern University, Chicago, IL; Wyeth Research, Cambridge, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; Centre Hospitalier Lyon-Sud, Pierre-B\u00e9nite; 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