{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:38:05Z","timestamp":1792705085144,"version":"4.5.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,5,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>There is a considerable variability in the level of molecular responses achieved with imatinib therapy in patients with chronic myeloid leukemia (CML). These differences could result from variable therapy adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-seven patients with chronic-phase CML treated with imatinib 400 mg\/d for a median of 59.7 months (range, 25 to 104 months) who had achieved complete cytogenetic response had adherence monitored during a 3-month period by using a microelectronic monitoring device. Adherence was correlated with levels of molecular response. Other factors that could influence outcome were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median adherence rate was 98% (range, 24% to 104%). Twenty-three patients (26.4%) had adherence \u2264 90%; in 12 of these patients (14%), adherence was \u2264 80%. There was a strong correlation between adherence rate (\u2264 90% or &gt; 90%) and the 6-year probability of a 3-log reduction (also known as major molecular response [MMR]) in BCR-ABL1 transcripts (28.4% v 94.5%; P &lt; .001) and also complete molecular response (CMR; 0% v 43.8%; P = .002). Multivariate analysis identified adherence (relative risk [RR], 11.7; P = .001) and expression of the molecular human organic cation transporter-1 (RR, 1.79; P = .038) as the only independent predictors for MMR. Adherence was the only independent predictor for CMR. No molecular responses were observed when adherence was \u2264 80% (P &lt; .001). Patients whose imatinib doses were increased had poor adherence (86.4%). In this latter population, adherence was the only independent predictor for inability to achieve an MMR (RR, 17.66; P = .006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with CML treated with imatinib for some years, poor adherence may be the predominant reason for inability to obtain adequate molecular responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.26.3087","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T22:46:24Z","timestamp":1271112384000},"page":"2381-2388","source":"Crossref","is-referenced-by-count":751,"title":["Adherence Is the Critical Factor for Achieving Molecular Responses in Patients With Chronic Myeloid Leukemia Who Achieve Complete Cytogenetic Responses on Imatinib"],"prefix":"10.1200","volume":"28","author":[{"given":"David","family":"Marin","sequence":"first","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bazeos","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois-Xavier","family":"Mahon","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Eliasson","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Milojkovic","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bua","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Apperley","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Szydlo","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritti","family":"Desai","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Paliompeis","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Latham","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Foroni","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Molimard","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; and University of London, School of Pharmacy; and Centre for Sexual Health and HIV Research, University College of London, London, United Kingdom; Laboratoire H\u00e9matopo\u00ef\u00e8se Leuc\u00e9mique et Cible Th\u00e9rapeutique, Universit\u00e9 Victor S\u00e9galen Bordeaux 2; and the Department of Clinical Pharmacology and Toxicology, Hospitalier Universitaire de Bordeaux, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Reid","sequence":"additional","affiliation":[{"name":"From the Departments of Haematology and of Pharmacy, Imperial College London, Hammersmith Hospital; 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