{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:40:59Z","timestamp":1792068059015,"version":"4.4.0"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,8,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We determined whether the association between breast density and breast cancer risk and cancer severity differs according to menopausal status and postmenopausal hormone therapy (HT) use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We collected data on 587,369 women who underwent 1,349,027 screening mammography examinations; 14,090 women were diagnosed with breast cancer. We calculated 5-year breast cancer risk from a survival model for subgroups of women classified by their Breast Imaging Reporting and Data System (BIRADS) breast density, age, menopausal status, and current HT use, assuming a body mass index of 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Odds of advanced (ie, IIb, III, IV) versus early (ie, I, IIa) stage invasive cancer was calculated according to BIRADS density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Breast cancer risk was low among women with low density (BIRADS-1): women age 55 to 59 years, 5-year risk was 0.8% (95% CI, 0.6 to 0.9%) for non-HT users and 0.9% (95% CI, 0.7% to 1.1%) for estrogen and estrogen plus progestin users. Breast cancer risk was high among women with very high density (BIRADS-4), particularly estrogen plus progestin users: women age 55 to 59 years, 5-year risk was 2.4% (95% CI, 2.0% to 2.8%) for non-HT users, 3.0% (95% CI, 2.6% to 3.5%) for estrogen users, and 4.2% (95% CI, 3.7% to 4.6%) for estrogen plus progestin users. Advanced-stage breast cancer risk was increased 1.7-fold for postmenopausal HT users who had very high density (BIRADS-4) compared to those with average density (BIRADS-2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postmenopausal women with high breast density are at increased risk of breast cancer and should be aware of the added risk of taking HT, especially estrogen plus progestin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2009.26.4770","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T01:11:59Z","timestamp":1279588319000},"page":"3830-3837","source":"Crossref","is-referenced-by-count":191,"title":["Breast Cancer Risk by Breast Density, Menopause, and Postmenopausal Hormone Therapy Use"],"prefix":"10.1200","volume":"28","author":[{"given":"Karla","family":"Kerlikowske","sequence":"first","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Cook","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana S.M.","family":"Buist","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve R.","family":"Cummings","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Vachon","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Vacek","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Miglioretti","sequence":"additional","affiliation":[{"name":"From the General Internal Medicine Section, University of California; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA; Group Health Research Institute, Biostatistics Unit, Group Health Cooperative; University of Washington, Seattle, WA; Mayo Clinic College of Medicine, Rochester, MN; and the University of Vermont, College of Medicine, Burlington, VT."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00003"},{"key":"B3","first-page":"1382","volume":"11","author":"Vachon C","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.1.30"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.151"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0327"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050025"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0559"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1950"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301020589"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.24.3243"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.4.9308451"},{"key":"B13","volume-title":"The American College of Radiology Breast Imaging Reporting and Data System (BI-RADS)","author":"American College of Radiology","year":"2003","edition":"4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.20.1546"},{"key":"B15","volume-title":"AJCC Cancer Staging Manual","author":"Greene F","year":"2001","edition":"6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2005.00323.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7983-4_14"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2342040048"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.14.1647"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.7332"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF01833517"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj439"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0490"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.2.171"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.7166"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0762"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh106"},{"key":"B28","volume-title":"Paper presented at 31st Annual Meeting of the San Antonio Breast Cancer Symposium","author":"Cuzick"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026514032085"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013390"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-5-200803040-00004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.9.670"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.21.1622"},{"key":"B34","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1158\/1055-9965.715.13.5","volume":"13","author":"Vacek PM","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk066"},{"key":"B36","first-page":"1","volume-title":"ACOG Educational Bulletin 247","author":"American College of Obstetricians and Gyne-cologists","year":"1998"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.23.1801"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.12.004"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.26.4770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T02:04:23Z","timestamp":1685671463000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.26.4770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,20]]},"references-count":38,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2010,8,20]]}},"alternative-id":["10.1200\/JCO.2009.26.4770"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.26.4770","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4753966.4649064","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,20]]}}}