{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:20:34Z","timestamp":1774326034149,"version":"3.50.1"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The activity of rituximab in pediatric B-cell non-Hodgkin's lymphoma (B-NHL) has not yet been determined. We conducted a phase II window study to examine activity and tolerability of rituximab in newly diagnosed pediatric B-NHL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients younger than age 19 years with CD20<jats:sup>+<\/jats:sup> B-NHL with at least one measurable site were eligible. Treatment consisted of rituximab at 375 mg\/m<jats:sup>2<\/jats:sup> administered intravenously on day 1; concomitant therapy consisted of rasburicase, intrathecally (IT) triple drug (methotrexate, cytarabine, and prednisolone) on days 1 and 3 for CNS-positive patients and steroids only for anaphylaxis. Response criterion was the product of the two largest perpendicular diameters of one to three lesions and\/or the percentage of blasts in bone marrow (BM) or peripheral blood (PB) within 24 hours before rituximab and on day 5. Responders had \u2265 25% decrease of at least one lesion or BM or PB blasts and no disease progress at other sites. Response rate (RR) was set at 45% for unfavorable activity or at 65% for favorable activity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> From April 2004 to August 2008, 136 patients were enrolled. National Cancer Institute Common Toxicity Criteria 3\/4 toxicities attributable to rituximab were general condition, 15%; fatigue, 13%; anaphylaxis, 7%; infection, 3%; glutamic-oxaloacetic transaminase\/glutamic-pyruvic transaminase, 8%; no capillary leakage; and no toxic death. Forty-nine patients were not evaluable for response because of withdrawal from the study (n = 16), IT therapy in CNS-negative patients (n = 8), corticosteroid treatment (n = 3), technical inadequacy of response evaluation (n = 21), or no evaluable lesion (n = 1). Of 87 evaluable patients, 36 were responders (RR, 41.4%; 95% CI, 31% to 52%); among them, 27 of 67 with Burkitt lymphoma and seven of 15 with diffuse large B-cell lymphoma. A response was more frequently observed in BM (12 of 18) compared with solid tumor lesions (36 of 108; P = .007). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Rituximab is active as a single-agent in pediatric B-NHL even though the RR was lower than requested in the phase II plan. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.26.6791","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T01:53:40Z","timestamp":1275443620000},"page":"3115-3121","source":"Crossref","is-referenced-by-count":155,"title":["Phase II Window Study on Rituximab in Newly Diagnosed Pediatric Mature B-Cell Non-Hodgkin's Lymphoma and Burkitt Leukemia"],"prefix":"10.1200","volume":"28","author":[{"given":"Andrea","family":"Meinhardt","sequence":"first","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Kontny","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klingebiel","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Berthold","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gritta","family":"Janka-Schaub","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edita","family":"Kabickova","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; University of Cologne, Cologne; University Medical Center..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Reiter","sequence":"additional","affiliation":[{"name":"From the Non-Hodgkin's Lymphoma\u2013Berlin-Frankfurt-M\u00fcnster Study Center, Justus Liebig University Giessen, Giessen; University Hospital Schleswig-Holstein\/Campus Kiel, Kiel; Center of Child and Adolescent Medicine, Hannover Medical School, Hannover; Center of Child and Adolescent Medicine, Heinrich Heine University, D\u00fcsseldorf; Center of Child and Adolescent Medicine, Albert Ludwigs University, Freiburg; Johann Wolfgang Goethe University, Frankfurt; 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