{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:37:59Z","timestamp":1790203079949,"version":"4.1.0"},"reference-count":19,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,4,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Allogeneic hematopoietic cell transplantation (HCT) is curative therapy for chronic myeloid leukemia (CML), but its long-term outcomes are not well described. We studied the long-term outcomes of CML patients in first chronic phase who receive an allogeneic HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Our study included 2,444 patients who received myeloablative HCT for CML in first chronic phase between 1978 and 1998 and survived in continuous complete remission for at least 5 years (median follow-up, 11 years; range, 5 to 25 years). Donor sources were human leukocyte antigen\u2013matched siblings in 1,692 patients, unrelated donors in 639 patients, and other related donors in 113 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival rates at 15 years were 88% (95% CI, 86% to 90%) for sibling HCT and 87% (95% CI, 83% to 90%) for unrelated donor HCT. Corresponding cumulative incidences of relapse were 8% (95% CI, 7% to 10%) and 2% (95% CI, 1% to 4%), respectively. The latest relapse was reported 18 years post-HCT. In multivariable analyses, history of chronic graft-versus-host disease increased risks of late overall mortality and nonrelapse mortality but reduced risks of relapse. In comparison with age-, race-, and sex-adjusted normal populations, the mortality of HCT recipients was significantly higher until 14 years post-HCT; thereafter, mortality rates were similar to those of the general population (relative mortality ratio at 15 years, 2.3; 95% CI, 0 to 4.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recipients of allogeneic HCT for CML in first chronic phase who remain in remission for at least 5 years have favorable subsequent long-term survival, and their mortality rates eventually approach those of the general population.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.26.7757","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T05:29:26Z","timestamp":1268112566000},"page":"1888-1895","source":"Crossref","is-referenced-by-count":118,"title":["Relapse and Late Mortality in 5-Year Survivors of Myeloablative Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia in First Chronic Phase"],"prefix":"10.1200","volume":"28","author":[{"given":"John M.","family":"Goldman","sequence":"first","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet S.","family":"Majhail","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Klein","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Sobocinski","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Arora","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Douglas","family":"Rizzo","sequence":"additional","affiliation":[{"name":"From the Imperial College at Hammersmith Hospital, London, United Kingdom; Center for International Blood and Marrow Transplant Research; University of Minnesota, Minneapolis, MN; and Medical College of Wisconsin, Milwaukee, WI."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06582.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-141689"},{"key":"B3","first-page":"1810","volume":"91","author":"Gale RP","year":"1998","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-038943"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.7740"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.03.013"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410103"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403821"},{"key":"B9","first-page":"7","volume":"15","author":"Pasquini M","year":"2009","journal-title":"CIBMTR Newsletter"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.05.007"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08272-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.406"},{"key":"B13","first-page":"825","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.1007\/b97377","volume-title":"Survival Analysis: Techniques for Censored and Truncated Data","author":"Klein JP","year":"2003","edition":"2"},{"key":"B15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc B"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2307\/2531494"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176346152"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082933"},{"key":"B19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbmt.2005.09.012","volume":"12","author":"Rizzo JD","year":"2006","journal-title":"Biol Blood Marrow Transplant"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.26.7757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T02:10:41Z","timestamp":1739931041000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.26.7757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,10]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,4,10]]}},"alternative-id":["10.1200\/JCO.2009.26.7757"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.26.7757","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,10]]}}}