{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:43:03Z","timestamp":1769856183420,"version":"3.49.0"},"reference-count":53,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Sorafenib is a kinase inhibitor targeting Raf and other kinases (ie, vascular endothelial growth factor receptor [VEGFR], platelet-derived growth factor receptor [PDGFR], Flt3, and c-KIT). This study assessed its activity and tolerability in patients with recurrent ovarian cancer (OC) or primary peritoneal carcinomatosis (PPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This open-label, multi-institutional, phase II study used a two-stage design. Eligible patients had persistent or recurrent OC\/PPC after one to two prior cytotoxic regimens, and they experienced progression within 12 months of platinum-based therapy. Treatment consisted of sorafenib 400 mg orally twice per day. Primary end points were progression-free survival (PFS) at 6 months and toxicity by National Cancer Institute criteria. Secondary end points were tumor response and duration of PFS and overall survival. Biomarker analyses included measurement of ERK and b-Raf expression in tumors and phosphorylation of ERK (pERK) in peripheral-blood lymphocytes (PBLs) before and after 1 month of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy-three patients were enrolled, of which 71 were eligible. Fifty-nine eligible patients (83%) had measurable disease, and 12 (17%) had detectable disease. Significant grade 3 or 4 toxicities included the following: rash (n = 7), hand-foot syndrome (n = 9), metabolic (n = 10), GI (n = 3), cardiovascular (n = 2), and pulmonary (n = 2). Only patients with measurable disease were used to assess efficacy. Fourteen survived progression free for at least 6 months (24%; 90% CI, 15% to 35%). Two patients had partial responses (3.4%; 90% CI, 1% to 10%); 20 had stable disease; 30 had progressive disease; and seven could not have their tumor assessed. ERK and b-Raf were expressed in all tumors. Exploratory analyses indicated that pERK in post-treatment PBL specimens was associated with PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sorafenib has modest antitumor activity in patients with recurrent OC, but the activity was at the expense of substantial toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.26.7856","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T05:52:17Z","timestamp":1290491537000},"page":"69-75","source":"Crossref","is-referenced-by-count":148,"title":["Activity of Sorafenib in Recurrent Ovarian Cancer and Primary Peritoneal Carcinomatosis: A Gynecologic Oncology Group Trial"],"prefix":"10.1200","volume":"29","author":[{"given":"Daniela","family":"Matei","sequence":"first","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Sill","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather A.","family":"Lankes","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"DeGeest","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Bristow","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mutch","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Diane","family":"Yamada","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cohn","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Calvert","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Farley","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuel F.","family":"Petricoin","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Birrer","sequence":"additional","affiliation":[{"name":"From the Indiana University and Simon Cancer Center, Indianapolis, IN; Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute; and University at Buffalo, Buffalo, NY; University of Iowa Hospitals and Clinics, Iowa City, IA; Johns Hopkins Oncology Center, Baltimore, MD; Washington University School of Medicine, St Louis, MO; University of Chicago, Chicago, IL; Columbus Cancer Council, Columbus, OH; Center for Applied Proteomics and Molecular Medicine, George Mason University..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"key":"B2","first-page":"1502","volume-title":"Cancer, Principles and Practice of Oncology","author":"Ozols R","year":"1997"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.14.3312"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.10.104"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480508"},{"key":"B6","first-page":"157","volume":"2","author":"van't Veer LJ","year":"1988","journal-title":"Oncogene"},{"key":"B7","first-page":"1489","volume":"53","author":"Mok SC","year":"1993","journal-title":"Cancer Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006611220434"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1993.12.623"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00264-6"},{"key":"B11","first-page":"151","volume":"27","author":"Kurman RJ","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800306"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1088::AID-CNCR12>3.0.CO;2-2"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1581::AID-CNCR21>3.0.CO;2-T"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.6.484"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.2139"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0154"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21520"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209232"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11561"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.7.506"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0271fje"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1377"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0595"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050711"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204265"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.509"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.04.014"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0462"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19981030)17:20<2301::AID-SIM927>3.0.CO;2-X"},{"key":"B32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox D","year":"1972","journal-title":"J Royal Stat Soc B"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.11.710"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19961230)15:24<2797::AID-SIM290>3.0.CO;2-V"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6723"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.3441"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3279"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2871"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4823"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3816\/CGC.2009.n.003"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.6.779"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.10.017"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.040"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00680.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.1509"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.0782"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.1939"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1432"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20092"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1430"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.11.055"},{"key":"B52","first-page":"278s","volume":"25","author":"Welch S","year":"2007","journal-title":"J Clin Oncol"},{"key":"B53","doi-asserted-by":"crossref","first-page":"276s","DOI":"10.1200\/jco.2006.24.18_suppl.5084","volume":"24","author":"Welch S","year":"2006","journal-title":"J Clin Oncol"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.26.7856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T04:29:28Z","timestamp":1740716968000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.26.7856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1,1]]}},"alternative-id":["10.1200\/JCO.2009.26.7856"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.26.7856","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,1]]}}}