{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:45:28Z","timestamp":1791909928015,"version":"4.3.4"},"reference-count":43,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,8,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Fractionated radioimmunotherapy targeting CD22 may substantially improve responses and outcome in non-Hodgkin's lymphoma (NHL). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> A multicenter trial evaluated two or three weekly infusions of yttrium-90 (<jats:sup>90<\/jats:sup>Y) epratuzumab tetraxetan (humanized anti-CD22 antibody) in 64 patients with relapsed\/refractory NHL, including 17 patients who underwent prior autologous stem-cell transplantation (ASCT). Objective (OR) and complete responses (CR\/complete response unconfirmed [CRu]), as well as progression-free survival (PFS), were determined. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At the maximum total <jats:sup>90<\/jats:sup>Y dose of 45 mCi\/m<jats:sup>2<\/jats:sup> (1,665 MBq\/m<jats:sup>2<\/jats:sup>), grade 3 to 4 hematologic toxicities were reversible to grade 1 in patients with less than 25% bone marrow involvement. The overall OR rate and median PFS for all 61 evaluable patients was 62% (CR\/CRu, 48%) and 9.5 months, respectively. Patients without prior ASCT obtained high OR rates of 71% (CR\/CRu, 55%) across all NHL subtypes and <jats:sup>90<\/jats:sup>Y doses, even in poor-risk categories (refractory to last anti-CD20\u2013containing regimen, 73% [CR\/CRu, 60%]; bulky disease: 71% [CR\/CRu, 43%]). Patients with prior ASCT received lower doses, but achieved an OR rate of 41% (CR\/CRu, 29%). For patients with follicular lymphoma (FL), OR rates and median PFS increased with total <jats:sup>90<\/jats:sup>Y-dose, reaching 100% (CR\/CRu, 92%) and 24.6 months, respectively, at the highest dose levels (&gt; 30 mCi\/m<jats:sup>2<\/jats:sup> total <jats:sup>90<\/jats:sup>Y-dose [1,110 MBq\/m<jats:sup>2<\/jats:sup>]). Further, patients with FL refractory to prior anti-CD20\u2013containing regimens achieved 90% (nine of 10 patients) OR and CR\/CRu rates and a median PFS of 21.5 months. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Fractionated anti-CD22 radioimmunotherapy provides high total doses of <jats:sup>90<\/jats:sup>Y, yielding high rates of durable CR\/CRus in relapsed\/refractory NHL, resulting in 20 mCi\/m<jats:sup>2<\/jats:sup> \u00d7 2 weeks as the recommended dose for future studies. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.27.7863","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T03:55:29Z","timestamp":1278993329000},"page":"3709-3716","source":"Crossref","is-referenced-by-count":103,"title":["High Rates of Durable Responses With Anti-CD22 Fractionated Radioimmunotherapy: Results of a Multicenter, Phase I\/II Study in Non-Hodgkin's Lymphoma"],"prefix":"10.1200","volume":"28","author":[{"given":"Franck","family":"Morschhauser","sequence":"first","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Kraeber-Bod\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Wegener","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Harousseau","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Petillon","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Huglo","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz H.","family":"Tr\u00fcmper","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Meller","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pfreundschuh","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl-Martin","family":"Kirsch","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Naumann","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kropp","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Horne","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Teoh","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Le Gouill","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bodet-Milin","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Chatal","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"From the Service des Maladies du Sang, Centre Hospitalier Regional, L'Universitaire de Lille; Institut de Biologie, L'Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 892, Centre de Recherche en Canc\u00e9rologie Nantes-Angers; Centre Hospitalier Universitaire, Nantes; Centre Ren\u00e9 Gauducheau, Institut R\u00e9gional du Cancer Nantes-Atlantique, Nantes-Saint-Herblain, France; Immunomedics, Morris Plains; Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ; Georg..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197806222982503"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.4.226"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708875"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2825"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008389119525"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"B7","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood-2005-01-0016","volume":"106","author":"Hiddemann W","year":"2005","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3793"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.076"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.4.1259"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1316"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.19.3918"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.06.055"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.2015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.8198"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041511"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22617"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.5447"},{"key":"B20","doi-asserted-by":"crossref","first-page":"350a","DOI":"10.1182\/blood-2001-12-0276","volume":"100","author":"Cesano A","year":"2002","journal-title":"Blood"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.10.1341"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.082"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0294"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560413"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.05.007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050371"},{"key":"B27","first-page":"77","volume":"44","author":"Griffiths GL","year":"2003","journal-title":"J Nucl Med"},{"key":"B28","first-page":"2000","volume":"44","author":"Sharkey RM","year":"2003","journal-title":"J Nucl Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10304"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0172"},{"key":"B31","unstructured":"NL Harris,  JA Ferry :  Classification of non-Hodgkin's lymphoma, in Knowles DM (ed): Neoplastic Hematopathology (ed 2) 691\u2013 753,2001 Philadelphia, PA Lippincott Williams & Wilkins"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10591"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21882"},{"key":"B36","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1182\/blood-2004-04-1323","volume":"104","author":"Forstpointner R","year":"2004","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.017"},{"key":"B38","doi-asserted-by":"crossref","first-page":"560a","DOI":"10.1182\/blood.V110.11.560.560","volume":"110","author":"Vanazzi A","year":"2007","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.8294"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-175653"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132142"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-188896"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0404"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.27.7863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:10:14Z","timestamp":1653520214000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.27.7863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,10]]},"references-count":43,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2010,8,10]]}},"alternative-id":["10.1200\/JCO.2009.27.7863"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.27.7863","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,10]]}}}