{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:05:40Z","timestamp":1771869940568,"version":"3.50.1"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,6,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The efficacy and safety of cyclophosphamide, vincristine, and prednisone (CVP) followed by tositumomab and iodine-131 (<jats:sup>131<\/jats:sup>I) \u2013tositumomab therapy were evaluated in a multicenter phase II study in patients with untreated low-grade follicular lymphoma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients received six cycles of CVP followed by one cycle of tositumomab and <jats:sup>131<\/jats:sup>I-tositumomab (one dosimetric dose and one therapeutic dose). The treatment was evaluated for efficacy and safety. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> All 30 patients enrolled completed CVP as well as tositumomab and <jats:sup>131<\/jats:sup>I-tositumomab therapy. The overall response rate after completion of therapy was 100%, with 28 patients (93%) achieving a complete response (CR) and two patients achieving a partial response. Of the 17 patients with bone marrow involvement at enrollment, 15 achieved a confirmed CR. Fourteen of 15 patients with bulky disease (\u2265 5 cm) had a CR after treatment completion. After a median follow-up of 8.4 years, the median response duration had not been reached (range, 3 to 111+ months). Five-year progression-free and overall survival rates were 56% and 83%, respectively. The most common grade \u2265 3 hematologic adverse events were neutropenia (87%) and thrombocytopenia (37%). Nineteen patients received growth factor support, and three required blood product transfusions. No patients developed human antimurine antibodies. Two patients developed myelodysplastic syndrome\/acute myeloid leukemia. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> These mature data demonstrate that sequential therapy with a non-anthracycline\u2013containing regimen comprising CVP followed by one cycle of tositumomab and <jats:sup>131<\/jats:sup>I-tositumomab produced high response rates with adequate safety and durable remissions and that this regimen represents a highly active treatment for first-line therapy of follicular non-Hodgkin's lymphoma. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2009.27.8325","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T04:29:45Z","timestamp":1273552185000},"page":"3035-3041","source":"Crossref","is-referenced-by-count":52,"title":["Cyclophosphamide, Vincristine, and Prednisone Followed by Tositumomab and Iodine-131\u2013Tositumomab in Patients With Untreated Low-Grade Follicular Lymphoma: Eight-Year Follow-Up of a Multicenter Phase II Study"],"prefix":"10.1200","volume":"28","author":[{"given":"Brian K.","family":"Link","sequence":"first","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Martin","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morton","family":"Coleman","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Leonard","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2004.1.203"},{"key":"B2","first-page":"S72","volume":"83","author":"Buske C","year":"2004","journal-title":"Ann Hematol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.503"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1495"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1674"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"B7","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood-2005-01-0016","volume":"106","author":"Hiddemann W","year":"2005","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3696"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.7952"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.1561"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5376"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0756"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.076"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308123290703"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.00.9217"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.4.1259"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.0892"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041511"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.19.3918"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1316"},{"key":"B21","volume":"114","author":"Kaminski MS","year":"2009","journal-title":"51st ASH Annual Meeting Abstracts"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.8198"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.803"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.2015"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12120"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2009.27.8325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:18:40Z","timestamp":1653524320000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2009.27.8325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,20]]},"references-count":26,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2010,6,20]]}},"alternative-id":["10.1200\/JCO.2009.27.8325"],"URL":"https:\/\/doi.org\/10.1200\/jco.2009.27.8325","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,20]]}}}