{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:58:45Z","timestamp":1790521125270,"version":"4.1.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,10,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We report the long-term results of a randomized clinical trial comparing induction therapy with once per week for 4 weeks single-agent rituximab alone versus induction followed by 4 cycles of maintenance therapy every 2 months in patients with follicular lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients (prior chemotherapy 138; chemotherapy-naive 64) received single-agent rituximab and if nonprogressive, were randomly assigned to no further treatment (observation) or four additional doses of rituximab given at 2-month intervals (prolonged exposure).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At a median follow-up of 9.5 years and with all living patients having been observed for at least 5 years, the median event-free survival (EFS) was 13 months for the observation and 24 months for the prolonged exposure arm (P &lt; .001). In the observation arm, patients without events at 8 years were 5%, while in the prolonged exposure arm they were 27%. Of previously untreated patients receiving prolonged treatment after responding to rituximab induction, at 8 years 45% were still without event. The only favorable prognostic factor for EFS in a multivariate Cox regression was the prolonged rituximab schedule (hazard ratio, 0.59; 95% CI, 0.39 to 0.88; P = .009), whereas being chemotherapy naive, presenting with stage lower than IV, and showing a VV phenotype at position 158 of the Fc-gamma RIIIA receptor were not of independent prognostic value. No long-term toxicity potentially due to rituximab was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An important proportion of patients experienced long-term remission after prolonged exposure to rituximab, particularly if they had no prior treatment and responded to rituximab induction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2010.28.4786","type":"journal-article","created":{"date-parts":[[2010,8,9]],"date-time":"2010-08-09T23:32:15Z","timestamp":1281396735000},"page":"4480-4484","source":"Crossref","is-referenced-by-count":204,"title":["Long-Term Follow-Up of Patients With Follicular Lymphoma Receiving Single-Agent Rituximab at Two Different Schedules in Trial SAKK 35\/98"],"prefix":"10.1200","volume":"28","author":[{"given":"Giovanni","family":"Martinelli","sequence":"first","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fang","family":"Hsu Schmitz","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Utiger","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cerny","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Hess","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bassi","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmie","family":"Okkinga","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Stupp","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Stahel","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Heizmann","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vorobiof","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lohri","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Dietrich","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; Kantonsspital, Onkologie, Liestal; Hopitaux Universitaires de Gen\u00e8ve, Service d'Oncologie,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Zucca","sequence":"additional","affiliation":[{"name":"From the Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy; Swiss Group for Clinical Cancer Research Coordinating Centre; Institute of Medical Oncology, Inselspital, Bern; Kantonsspital, Onkologie\/H\u00e4matologie, St Gallen; Centre Hospitalier Universitaire Vaudois, Lausanne; Universit\u00e4tsspital Z\u00fcrich, Foschungslabor f\u00fcr Onkologie, Z\u00fcrich; Kantonsspital, Zentrum f\u00fcr Onkologie\/H\u00e4matologie, Aarau; 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