{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:14:34Z","timestamp":1789370074377,"version":"build-2803163510"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,9,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Vitamin D insufficiency is common in the United States, with low levels linked in some studies to higher cancer incidence, including non-Hodgkin's lymphoma (NHL). Recent data also suggest that vitamin D insufficiency is related to inferior prognosis in some cancers, although there are no data for NHL. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We tested the hypothesis that circulating 25-hydroxyvitamin D [25(OH)D] levels are predictive of event-free survival (EFS) and overall survival (OS) in a prospective cohort of 983 newly diagnosed patients with NHL. 25(OH)D and 1,25-dihydroxyvitamin D [1,25(OH)<jats:sub>2<\/jats:sub>D] levels were measured by liquid chromatography-tandem mass spectrometry. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Mean age at diagnosis was 62 years (range, 19 to 94 years); 44% of patients had insufficient 25(OH)D levels (&lt; 25 ng\/mL) within 120 days of diagnosis. Median follow-up was 34.8 months; 404 events and 193 deaths (168 from lymphoma) occurred. After adjusting for known prognostic factors and treatment, 25(OH)D insufficient patients with diffuse large B-cell lymphoma (DLBCL) had inferior EFS (hazard ratio [HR], 1.41; 95% CI, 0.98 to 2.04) and OS (HR, 1.99; 95% CI, 1.27 to 3.13); 25(OH)D insufficient patients with T-cell lymphoma also had inferior EFS (HR, 1.94; 95% CI, 1.04 to 3.61) and OS (HR, 2.38; 95% CI, 1.04 to 5.41). There were no associations with EFS for the other NHL subtypes. Among patients with DLBCL and T-cell lymphoma, higher 1,25(OH)<jats:sub>2<\/jats:sub>D levels were associated with better EFS and OS, suggesting that any putative tumor 1-\u03b1-hydroxylase activity did not explain the 25(OH)D associations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> 25(OH)D insufficiency was associated with inferior EFS and OS in DLBCL and T-cell lymphoma. Whether normalizing vitamin D levels in these patients improves outcomes will require testing in future trials. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2010.28.6674","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T02:41:29Z","timestamp":1282012889000},"page":"4191-4198","source":"Crossref","is-referenced-by-count":178,"title":["Vitamin D Insufficiency and Prognosis in Non-Hodgkin's Lymphoma"],"prefix":"10.1200","volume":"28","author":[{"given":"Matthew T.","family":"Drake","sequence":"first","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana N.","family":"Micallef","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Kelly","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; 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the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder J.","family":"Singh","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; the College of Medicine, University of Iowa, IA City, IA; and the University of Rochester, Rochester, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Weiner","sequence":"additional","affiliation":[{"name":"From the College of Medicine, Mayo Clinic, Rochester, MN; 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