{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:16:37Z","timestamp":1790223397215,"version":"4.1.0"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2010,10,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To analyze the outcome of allogeneic transplantation for mycosis fungoides and S\u00e9zary syndrome (MF\/SS) in terms of nonrelapse mortality (NRM), relapse\/progression (REL), progression-free survival (PFS), and overall survival (OS) and to identify factors associated with the outcome. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and Methods<\/jats:title><jats:p> Sixty patients with MF (n = 36) and SS (n = 24) who received a first allogeneic hematopoietic cell transplantation (HCT) from a matched related (mRD; n = 45) or unrelated donor (mUD; n = 15) between 1997 and 2007 and who were registered in the European Group for Blood and Marrow Transplantation database were analyzed: 37 men and 23 women, median age 46.5 years (range, 22 to 66 years). Forty-four patients had TNM stage IV, and 40 patients were at advanced phase at transplantation. Forty-four patients received reduced-intensity conditioning (RIC) regimens, and 25 underwent T-cell depletion (TCD). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Allogeneic transplantation in MF\/SS offers an estimated OS of 66% at 1 year and 54% at 3 years, primarily driven by donor type, disease phase, and type of conditioning. RIC decreased NRM (relative risk [RR] = 4.7; P = .008) without increasing REL, leading to a higher OS (RR = 2.8; P = .03). Advanced-phase disease increases REL (RR = 3.0; P = .03) and reduces PFS (RR = 4.4; P = .002) and OS (RR = 3.5; P = .023). Recipients of mRD allogeneic HCT had better PFS (RR = 2.7; P = .006) and OS (RR = 4.0; P = .001) than their mUD counterparts. The risk of REL increases with TCD (RR = 3.2; P = .005). Some patients who experience relapse can successfully undergo rescue treatment with donor lymphocyte infusions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Allogeneic transplantation is a valid therapeutic alternative for high-risk patients with advanced-stage MF\/SS. Our data also suggest the existence of a clinically relevant graft-versus-lymphoma effect in MF\/SS. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2010.29.3241","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T03:32:15Z","timestamp":1281411135000},"page":"4492-4499","source":"Crossref","is-referenced-by-count":180,"title":["Allogeneic Hematopoietic Cell Transplantation for Patients With Mycosis Fungoides and S\u00e9zary Syndrome: A Retrospective Analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation"],"prefix":"10.1200","volume":"28","author":[{"given":"Rafael F.","family":"Duarte","sequence":"first","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Canals","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Onida","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes","family":"Arranz","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Arcese","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; Heinrich Heine Universit\u00e4t, D\u00fcsseldorf; and Asklepios Klinik St..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Ferrant","sequence":"additional","affiliation":[{"name":"From the ICO-Hospital Duran i Reynals; Hospital Vall d'Hebron; Hospital Sant Pau i Santa Creu, Barcelona; Hospital Universitario de la Princesa, Madrid; Hospital de Navarra, Pamplona, Spain; Fondazione C\u00e0 Granda Ospedale Maggiore Policlinico, Milan; Policlinico Universtiario Tor Vergata, Rome; Policlinico Universitario di Modena, Modena, Italy; Imperial College, London, United Kingdom; Cliniques Universitaries St Luc, Brussels, Belgium; 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