{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:59:10Z","timestamp":1791104350196,"version":"4.1.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,5,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To evaluate the tolerability of escalating doses of stereotactic body radiation therapy in the treatment of localized prostate cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Eligible patients included those with Gleason score 2 to 6 with prostate-specific antigen (PSA) \u2264 20, Gleason score 7 with PSA \u2264 15, \u2264 T2b, prostate size \u2264 60 cm<jats:sup>3<\/jats:sup>, and American Urological Association (AUA) score \u2264 15. Pretreatment preparation required an enema and placement of a rectal balloon. Dose-limiting toxicity (DLT) was defined as grade 3 or worse GI\/genitourinary (GU) toxicity by Common Terminology Criteria of Adverse Events (version 3). Patients completed quality-of-life questionnaires at defined intervals. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Groups of 15 patients received 45 Gy, 47.5 Gy, and 50 Gy in five fractions (45 total patients). The median follow-up is 30 months (range, 3 to 36 months), 18 months (range, 0 to 30 months), and 12 months (range, 3 to 18 months) for the 45 Gy, 47.5 Gy, and 50 Gy groups, respectively. For all patients, GI grade \u2265 2 and grade \u2265 3 toxicity occurred in 18% and 2%, respectively, and GU grade \u2265 2 and grade \u2265 3 toxicity occurred in 31% and 4%, respectively. Mean AUA scores increased significantly from baseline in the 47.5-Gy dose level (P = .002) as compared with the other dose levels, where mean values returned to baseline. Rectal quality-of-life scores (Expanded Prostate Cancer Index Composite) fell from baseline up to 12 months but trended back at 18 months. In all patients, PSA control is 100% by the nadir + 2 ng\/mL failure definition. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Dose escalation to 50 Gy has been completed without DLT. A multicenter phase II trial is underway treating patients to 50 Gy in five fractions to further evaluate this experimental therapy. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2010.31.4377","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T03:50:38Z","timestamp":1301975438000},"page":"2020-2026","source":"Crossref","is-referenced-by-count":219,"title":["Phase I Dose-Escalation Study of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer"],"prefix":"10.1200","volume":"29","author":[{"given":"Thomas P.","family":"Boike","sequence":"first","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; and Prairie Lakes Hospital, Watertown, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Lotan","sequence":"additional","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; and Prairie Lakes Hospital, Watertown, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Chinsoo","family":"Cho","sequence":"additional","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; and Prairie Lakes Hospital, Watertown, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Brindle","sequence":"additional","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; and Prairie Lakes Hospital, Watertown, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"DeRose","sequence":"additional","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; and Prairie Lakes Hospital, Watertown, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Jin","family":"Xie","sequence":"additional","affiliation":[{"name":"From the University of Texas Southwestern, Dallas, TX; University of Minnesota, Minneapolis, MN; 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