{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:15:01Z","timestamp":1790612101462,"version":"4.1.0"},"reference-count":27,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Approximately one half of patients with Lambert-Eaton myasthenic syndrome (LEMS) have small-cell lung carcinomas (SCLC), aggressive tumors with poor prognosis. In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We derived a prediction score for SCLC in LEMS in a nationwide cohort of 107 Dutch patients, and validated it in a similar cohort of 112 British patients. A Dutch-English LEMS Tumor Association Prediction (DELTA-P) score was developed based on multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age at onset, smoking behavior, weight loss, Karnofsky performance status, bulbar involvement, male sexual impotence, and the presence of Sry-like high-mobility group box protein 1 serum antibodies were independent predictors for SCLC in LEMS. A DELTA-P score was derived allocating 1 point for the presence of each of the following items at or within 3 months from onset: age at onset \u2265 50 years, smoking at diagnosis, weight loss \u2265 5%, bulbar involvement, erectile dysfunction, and Karnofsky performance status lower than 70. The area under the curve of the receiver operating curve was 94.4% in the derivation cohort and 94.6% in the validation set. A DELTA-P score of 0 or 1 corresponded to a 0% to 2.6% chance of SCLC, whereas scores of 4, 5, and 6 corresponded to chances of SCLC of 93.5%, 96.6%, and 100%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The simple clinical DELTA-P score discriminated patients with LEMS with and without SCLC with high accuracy early in the course of LEMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2010.32.0440","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:23:48Z","timestamp":1295396628000},"page":"902-908","source":"Crossref","is-referenced-by-count":180,"title":["Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS"],"prefix":"10.1200","volume":"29","author":[{"given":"Maarten J.","family":"Titulaer","sequence":"first","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Maddison","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob K.","family":"Sont","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Wirtz","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hilton-Jones","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinse","family":"Klooster","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Willcox","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Potman","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.E. Sillevis","family":"Smitt","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.M.","family":"Kuks","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Roep","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Vincent","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silv\u00e8re M.","family":"van der Maarel","sequence":"additional","affiliation":[{"name":"From the Leiden University Medical Center, Leiden; Haga Hospital, the Hague; Erasmus University Medical Center, Rotterdam; University Medical Center Groningen, Groningen, the Netherlands; John Radcliffe Hospital, Oxford; and Queens Medical Centre, Nottingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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