{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:35Z","timestamp":1791420815609,"version":"4.3.3"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,7,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Vaccination with hybridoma-derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monocyte colony-stimulating factor (GM-CSF) induces follicular lymphoma (FL) \u2013specific immune responses. To determine the clinical benefit of this vaccine, we conducted a double-blind multicenter controlled phase III trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Treatment-naive patients with advanced stage FL achieving complete response (CR) or CR unconfirmed (CRu) after chemotherapy were randomly assigned two to one to receive either Id vaccine (Id-KLH + GM-CSF) or control (KLH + GM-CSF). Primary efficacy end points were disease-free survival (DFS) for all randomly assigned patients and DFS for randomly assigned patients receiving at least one dose of Id vaccine or control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 234 patients enrolled, 177 (81%) achieved CR\/CRu after chemotherapy and were randomly assigned. For 177 randomly assigned patients, including 60 patients not vaccinated because of relapse (n = 55) or other reasons (n = 5), median DFS between Id-vaccine and control arms was 23.0 versus 20.6 months, respectively (hazard ratio [HR], 0.81; 95% CI, 0.56 to 1.16; P = .256). For 117 patients who received Id vaccine (n = 76) or control (n = 41), median DFS after randomization was 44.2 months for Id-vaccine arm versus 30.6 months for control arm (HR, 0.62; 95% CI, 0.39 to 0.99; P = .047) at median follow-up of 56.6 months (range, 12.6 to 89.3 months). In an unplanned subgroup analysis, median DFS was significantly prolonged for patients receiving IgM-Id (52.9 v 28.7 months; P = .001) but not IgG-Id vaccine (35.1 v 32.4 months; P = .807) compared with isotype-matched control-treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vaccination with patient-specific hybridoma-derived Id vaccine after chemotherapy-induced CR\/CRu may prolong DFS in patients with FL. Vaccine isotype may affect clinical outcome and explain differing results between this and other controlled Id-vaccine trials.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2010.33.3005","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T04:36:38Z","timestamp":1306902998000},"page":"2787-2794","source":"Crossref","is-referenced-by-count":219,"title":["Vaccination With Patient-Specific Tumor-Derived Antigen in First Remission Improves Disease-Free Survival in Follicular Lymphoma"],"prefix":"10.1200","volume":"29","author":[{"given":"Stephen J.","family":"Schuster","sequence":"first","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. Muggia, New York University Cancer Institute, New York University School of Medicine, New York, NY; Jon..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sattva S.","family":"Neelapu","sequence":"additional","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. Muggia, New York University Cancer Institute, New York University School of Medicine, New York, NY; Jon..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry L.","family":"Gause","sequence":"additional","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. Muggia, New York University Cancer Institute, New York University School of Medicine, New York, NY; Jon..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Janik","sequence":"additional","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. Muggia, New York University Cancer Institute, New York University School of Medicine, New York, NY; Jon..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco M.","family":"Muggia","sequence":"additional","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. Muggia, New York University Cancer Institute, New York University School of Medicine, New York, NY; Jon..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon P.","family":"Gockerman","sequence":"additional","affiliation":[{"name":"Stephen J. Schuster, Elise A. Chong, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA; Sattva S. Neelapu, Donald A. Berry, Larry W. Kwak, The University of Texas MD Anderson Cancer Center, Houston, TX; Barry L. Gause, John E. Janik, Elaine S. Jaffe, Craig W. Reynolds, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Franco M. 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