{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:22:20Z","timestamp":1790706140165,"version":"4.1.0"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Adolescents (age 15 to 21 years) compared with younger children with mature B-cell non-Hodgkin's lymphoma (NHL) have been historically considered to have an inferior prognosis. We therefore analyzed the impact of age and other diagnostic factors on the risk of treatment failure in children and adolescents treated on the French-American-British Mature B-Cell Lymphoma 96 (FAB LMB 96) trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients were divided by risk: group A (limited), group B (intermediate), and group C (advanced), as previously described. Prognostic factors analyzed for event-free survival (EFS) included age (&lt; 15 v \u2265 15 years), stage (I\/II v III\/IV), primary site, lactate dehydrogenase (LDH), bone marrow\/CNS (BM\/CNS) involvement, and histology (diffuse large B-cell lymphoma v mediastinal B-cell lymphoma v Burkitt lymphoma or Burkitt-like lymphoma).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 3-year EFS for the whole cohort was 88% \u00b1 1%. Age was not associated as a risk factor for increased treatment failure in either univariate analysis (P = .15) or multivariate analysis (P = .58). Increased LDH (\u2265 2 \u00d7 upper limit of normal [ULN] v &lt; 2 \u00d7 ULN), primary site, and BM-positive\/CNS-positive disease were all independent risk factors associated with a significant increase in treatment failure rate (relative risk, 2.0; P &lt; .001, P &lt; .012, and P &lt; .001, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LDH level at diagnosis, mediastinal disease, and combined BM-positive\/CNS-positive involvement are independent risk factors in children with mature B-cell NHL. Future studies should be developed to identify specific therapeutic strategies (immunotherapy) to overcome these risk factors and to identify the biologic basis associated with these prognostic factors in children with mature B-cell NHL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2010.33.3369","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T02:55:38Z","timestamp":1325645738000},"page":"387-393","source":"Crossref","is-referenced-by-count":152,"title":["Advanced Stage, Increased Lactate Dehydrogenase, and Primary Site, but Not Adolescent Age (\u2265 15 Years), Are Associated With an Increased Risk of Treatment Failure in Children and Adolescents With Mature B-Cell Non-Hodgkin's Lymphoma: Results of the FAB LMB 96 Study"],"prefix":"10.1200","volume":"30","author":[{"given":"Mitchell S.","family":"Cairo","sequence":"first","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sposto","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Gerrard","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Auperin","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanton C.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Harrison","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Pinkerton","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Raphael","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Patte","sequence":"additional","affiliation":[{"name":"Mitchell S. Cairo and Lauren Harrison, New York Medical College, Valhalla, NY; Richard Sposto, Keck School of Medicine, University of Southern California, Los Angeles, CA; Mary Gerrard, Sheffield Children's Hospital, Sheffield; Ross Pinkerton, Royal Marsden Hospital, Sutton, Surrey; Keith McCarthy, Gloucestershire Hospitals, National Health Service Foundation Trust, Gloucestershire, United Kingdom; Anne Auperin and Catherine Patte, Institut Gustave Roussy; Martine Raphael, Centre Hospitalier..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","first-page":"1962","volume-title":"Cancer Medicine","author":"Cairo MS","year":"2005","edition":"7"},{"key":"B2","first-page":"303","volume":"12","author":"Perkins SL","year":"1995","journal-title":"Semin Diagn 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