{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:03:03Z","timestamp":1792508583431,"version":"4.5.0"},"reference-count":19,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients with follicular lymphoma (FL) registered in the F2-study and initially managed without treatment were analyzed to describe the presentation and outcome of a watch and wait (W&amp;W) strategy in the rituximab era, to identify parameters for initiating treatment, and to evaluate whether initial W&amp;W could have deleterious effects on treatment efficacy after progression or relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Between 2003 and 2005, 120 patients selected from the 1,093 treatment-naive patients with FL in the F2-study cohort were initially managed expectantly (W&amp;W), and 107 patients were assessed. Most of these patients (80%) had disseminated disease with a low tumor burden according to Groupe d'Etudes des Lymphomes Folliculaires criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a median follow-up of 64 months, treatment was initiated in 54 patients (50%), with a median delay of 55 months for the entire cohort. In a univariate analysis, involvement of more than four nodal areas (hazard ratio [HR], 2.26) and serum albumin less than 3.5 g\/dL (HR, 3.51) were predictive of a shorter time to lymphoma treatment initiation. In a multivariate analysis, only involvement of more than four nodal areas remained significant (HR, 2.32). The 4-year freedom from treatment failure (FFTF) rate of W&amp;W patients (79%; 95% CI, 69% to 85%) was not inferior to that of a subgroup of 242 patients from the F2-study cohort with good prognosis characteristics who were initially treated with a rituximab-based regimen (69%; 95% CI, 61% to 76%; P = .103).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the rituximab era, patients with FL in a selected prognostically favorable group can still be managed with W&amp;W. W&amp;W does not seem to have detrimental effects on FFTF and overall survival rates after treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2010.33.4474","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T13:00:50Z","timestamp":1348578050000},"page":"3848-3853","source":"Crossref","is-referenced-by-count":120,"title":["Watchful Waiting in Low\u2013Tumor Burden Follicular Lymphoma in the Rituximab Era: Results of an F2-Study Database"],"prefix":"10.1200","volume":"30","author":[{"given":"Philippe","family":"Solal-C\u00e9ligny","sequence":"first","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bellei","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Anna","family":"Pesce","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pro","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. Ferreri, San Raffaele Scientific Institute, Milano, Italy; Peter..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J.M.","family":"Ferreri","sequence":"additional","affiliation":[{"name":"Philippe Solal-C\u00e9ligny, Institut de Canc\u00e9rologie de l'Ouest, Nantes\/Angers; Eric Deconinck, Centre Hospitalier Universitaire, Besan\u00e7on; No\u00ebl Milpied, Centre Hospitalier et Universitaire de Bordeaux, Bordeaux, France; Monica Bellei, Luigi Marcheselli, Emanuela Anna Pesce, Stefano Pileri, and Massimo Federico, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano Luminari, Istituto L. & A. Ser\u00e0gnoli, Universit\u00e0 di Bologna; Andr\u00e9s J.M. 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