{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:42:38Z","timestamp":1775619758463,"version":"3.50.1"},"reference-count":43,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,3,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Bisphosphonates are commonly used for the treatment of osteoporosis and bone metastases caused by breast cancer and were recently reported to be associated with a reduced risk of breast cancer, possibly acting through the mevalonate pathway, but their association with risk of other cancers is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>The Molecular Epidemiology of Colorectal Cancer study is a population-based, case-control study in northern Israel of patients with colorectal cancer and age-, sex-, clinic-, and ethnic group\u2013matched controls. Long-term use of bisphosphonates before diagnosis was assessed in a subset of 933 pairs of postmenopausal female patients and controls, enrolled in Clalit Health Services, using computerized pharmacy records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The use of bisphosphonates for more than 1 year before diagnosis, but not for less than 1 year, was associated with a significantly reduced relative risk (RR) of colorectal cancer (RR, 0.50; 95% CI, 0.35 to 0.71). This association remained statistically significant after adjustment in a model for vegetable consumption, sports activity, family history of colorectal cancer, body mass index, and use of low-dose aspirin, statins, vitamin D, and postmenopausal hormones (RR, 0.41; 95% CI, 0.25 to 0.67). Concomitant use of bisphosphonates and statins did not further reduce the risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of oral bisphosphonates for more than 1 year was associated with a 59% relative reduction in the risk of colorectal cancer, similar to the recently reported association of this drug class with reduction in breast cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2010.33.7485","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T04:07:56Z","timestamp":1297742876000},"page":"1146-1150","source":"Crossref","is-referenced-by-count":77,"title":["Use of Bisphosphonates and Reduced Risk of Colorectal Cancer"],"prefix":"10.1200","volume":"29","author":[{"given":"Gad","family":"Rennert","sequence":"first","affiliation":[{"name":"From the Carmel Medical Center, Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, and Clalit Health Services National Cancer Control Center, Haifa, Israel; and University of Michigan, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mila","family":"Pinchev","sequence":"additional","affiliation":[{"name":"From the Carmel Medical Center, Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, and Clalit Health Services National Cancer Control Center, Haifa, Israel; and University of Michigan, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedy S.","family":"Rennert","sequence":"additional","affiliation":[{"name":"From the Carmel Medical Center, Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, and Clalit Health Services National Cancer Control Center, Haifa, Israel; and University of Michigan, Ann Arbor, MI."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Gruber","sequence":"additional","affiliation":[{"name":"From the Carmel Medical Center, Bruce Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, and Clalit Health Services National Cancer Control Center, Haifa, Israel; 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