{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:19:29Z","timestamp":1789967969365,"version":"4.0.1"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2011,8,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The utility of [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose (FDG) positron emission tomography\u2013computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT\u2013positive (PET-positive) and PET-CT\u2013negative (PET-negative) patients. PET status correlated with conventional response criteria (P &lt; .001). Patients remaining PET positive had a significantly (P &lt; .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> [<jats:sup>18<\/jats:sup>F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.35.0736","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T06:15:27Z","timestamp":1310451327000},"page":"3194-3200","source":"Crossref","is-referenced-by-count":170,"title":["Positron Emission Tomography\u2013Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants"],"prefix":"10.1200","volume":"29","author":[{"given":"Judith","family":"Trotman","sequence":"first","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; Michael Fulham, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney; John Francis Seymour, Peter MacCallum Cancer Center and University of Melbourne, Melbourne; Cecily Forsyth, Wyong Hospital, Kanwal, Australia; Marion Fournier, Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, H\u00f4pital Lyon sud, Pierre-B\u00e9nite; Thierry Lamy, Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Fournier","sequence":"additional","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; Michael Fulham, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney; John Francis Seymour, Peter MacCallum Cancer Center and University of Melbourne, Melbourne; Cecily Forsyth, Wyong Hospital, Kanwal, Australia; Marion Fournier, Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, H\u00f4pital Lyon sud, Pierre-B\u00e9nite; Thierry Lamy, Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lamy","sequence":"additional","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; Michael Fulham, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney; John Francis Seymour, Peter MacCallum Cancer Center and University of Melbourne, Melbourne; Cecily Forsyth, Wyong Hospital, Kanwal, Australia; Marion Fournier, Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, H\u00f4pital Lyon sud, Pierre-B\u00e9nite; Thierry Lamy, Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Francis","family":"Seymour","sequence":"additional","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; Michael Fulham, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney; John Francis Seymour, Peter MacCallum Cancer Center and University of Melbourne, Melbourne; Cecily Forsyth, Wyong Hospital, Kanwal, Australia; Marion Fournier, Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, H\u00f4pital Lyon sud, Pierre-B\u00e9nite; Thierry Lamy, Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sonet","sequence":"additional","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; Michael Fulham, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Sydney; John Francis Seymour, Peter MacCallum Cancer Center and University of Melbourne, Melbourne; Cecily Forsyth, Wyong Hospital, Kanwal, Australia; Marion Fournier, Hospices Civils de Lyon, Groupe d'Etude des Lymphomes de l'Adulte, Recherche Clinique, H\u00f4pital Lyon sud, Pierre-B\u00e9nite; Thierry Lamy, Centre Hospitalier Universitaire (CHU) de Rennes, L'Institut..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Janikova","sequence":"additional","affiliation":[{"name":"Judith Trotman and Jane Estell, Concord Hospital; 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