{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:03:52Z","timestamp":1775027032756,"version":"3.50.1"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> In the United States, gastric cancer is rapidly fatal with a 25% 5-year survival. Of the few patients who survive, little is known about their demographic, clinical, and tumor characteristics. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Data regarding all cases of gastric and gastroesophageal junction (GEJ) adenocarcinoma diagnosed in California between 1988 and 2005 were obtained from the California Cancer Registry, a member of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program. A Cox proportional hazards model was constructed to understand the independent relationships of patient demographic, disease, and treatment factors with survival. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We identified 47,647 patients diagnosed with gastric or GEJ cancer. Of those, only 9,325 (20%) survived at least 3 years. Variables associated with longer survival were localized stage (hazard ratio [HR], 0.20), surgery with diagnosis in 2002 or later (HR, 0.34), surgery with diagnosis in 2001 or before (0.37), regional stage (HR, 0.53), chemotherapy (HR, 0.56), intestinal histology (HR, 0.74), well- or moderately differentiated tumors (HR, 0.76), radiation (HR, 0.80), Asian\/Pacific Islander race (HR, 0.81), treatment at an academic hospital (HR, 0.85), fundus\/body\/antrum location (HR, 0.90), highest socioeconomic status quintile (HR, 0.91), female sex (HR, 0.92), Hispanic race (HR, 0.92), and hospital size more than 150 beds (HR, 0.94). Kaplan-Meier curves showed longer median disease-specific survival (DSS) in patients with tumors originating in the fundus\/body\/antrum compared with esophagus\/cardia (13.4 v 10.8 months). Intestinal histology had significantly longer median DSS (28.9 months) compared with other (11.0 months) or diffuse (10.1 months) histology. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Patients who survive gastric and GEJ cancer more than 3 years after diagnosis have demographic and pathologic characteristics distinct from those who do not survive. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.35.8028","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T03:16:50Z","timestamp":1346815010000},"page":"3507-3515","source":"Crossref","is-referenced-by-count":106,"title":["Long-Term Survivors of Gastric Cancer: A California Population-Based Study"],"prefix":"10.1200","volume":"30","author":[{"given":"Pamela L.","family":"Kunz","sequence":"first","affiliation":[{"name":"Pamela L. Kunz, Matthew Gubens, George A. Fisher, and James M. Ford, Stanford University School of Medicine, Stanford; and Daphne Y. 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