{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:37:50Z","timestamp":1793036270527,"version":"4.5.0"},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,1,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The International Peripheral T-Cell Lymphoma Project was undertaken to better understand the subtypes of T-cell and natural killer (NK) \u2013cell lymphomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Angioimmunoblastic T-cell lymphoma (AITL) was diagnosed according to the 2001 WHO criteria by a central review process consisting of panels of expert hematopathologists. Clinical, pathologic, immunophenotyping, treatment, and survival data were correlated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1,314 patients, 243 (18.5%) were diagnosed with AITL. At presentation, generalized lymphadenopathy was noted in 76% of patients, and 89% had stages III to IV disease. Skin rash was observed in 21% of patients. Hemolytic anemia and hypergammoglobulinemia occurred in 13% and 30% of patients, respectively. Five-year overall and failure-free survivals were 33% and 18%, respectively. At presentation, prognostic models were evaluated, including the standard International Prognostic Index, which comprised the following factors: age \u2265 60 years, stages III to IV disease, lactic dehydrogenase (LDH) &gt; normal, extranodal sites (ENSs) &gt; one, and performance status (PS) \u2265 2; the Prognostic Index for Peripheral T-Cell Lymphoma, comprising: age \u2265 60 years, PS \u2265 2, LDH &gt; normal, and bone marrow involvement; and the alternative Prognostic Index for AITL (PIAI), comprising: age &gt; 60 years, PS \u2265 2, ENSs &gt; one, B symptoms, and platelet count &lt; 150 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L. The simplified PIAI had a low-risk group (zero to one factors), with 5-year survival of 44%, and a high-risk group (two to five factors), with 5-year survival of 24% (P = .0065).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AITL is a rare clinicopathologic entity characterized by an aggressive course and dismal outcome with current therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2011.37.3647","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T23:46:13Z","timestamp":1344296773000},"page":"240-246","source":"Crossref","is-referenced-by-count":323,"title":["Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project"],"prefix":"10.1200","volume":"31","author":[{"given":"Massimo","family":"Federico","sequence":"first","affiliation":[{"name":"Massimo Federico, Monica Bellei, and Stefano Luminari, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano A. Pileri, Universit\u00e0 di Bologna, Bologna, Italy; Thomas Rudiger, Stadisches Klinikum Karlsruhe, Karlsruhe, Germany; Bharat N. Nathwani, Ceders-Sinai Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA; Bertrand Coiffier, Hospices Civils de Lyon, Lyon; Nicholas Mounier, Hospital l'Archet, Nice, France; Nancy L. Harris, Massachusetts General Hospital and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rudiger","sequence":"additional","affiliation":[{"name":"Massimo Federico, Monica Bellei, and Stefano Luminari, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano A. Pileri, Universit\u00e0 di Bologna, Bologna, Italy; Thomas Rudiger, Stadisches Klinikum Karlsruhe, Karlsruhe, Germany; Bharat N. Nathwani, Ceders-Sinai Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA; Bertrand Coiffier, Hospices Civils de Lyon, Lyon; Nicholas Mounier, Hospital l'Archet, Nice, France; Nancy L. Harris, Massachusetts General Hospital and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bellei","sequence":"additional","affiliation":[{"name":"Massimo Federico, Monica Bellei, and Stefano Luminari, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano A. Pileri, Universit\u00e0 di Bologna, Bologna, Italy; Thomas Rudiger, Stadisches Klinikum Karlsruhe, Karlsruhe, Germany; Bharat N. Nathwani, Ceders-Sinai Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA; Bertrand Coiffier, Hospices Civils de Lyon, Lyon; Nicholas Mounier, Hospital l'Archet, Nice, France; Nancy L. Harris, Massachusetts General Hospital and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat N.","family":"Nathwani","sequence":"additional","affiliation":[{"name":"Massimo Federico, Monica Bellei, and Stefano Luminari, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano A. Pileri, Universit\u00e0 di Bologna, Bologna, Italy; Thomas Rudiger, Stadisches Klinikum Karlsruhe, Karlsruhe, Germany; Bharat N. Nathwani, Ceders-Sinai Medical Center and University of Southern California Keck School of Medicine, Los Angeles, CA; Bertrand Coiffier, Hospices Civils de Lyon, Lyon; Nicholas Mounier, Hospital l'Archet, Nice, France; Nancy L. Harris, Massachusetts General Hospital and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"Massimo Federico, Monica Bellei, and Stefano Luminari, Universit\u00e0 di Modena e Reggio Emilia, Modena; Stefano A. 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