{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:18:17Z","timestamp":1791580697823,"version":"4.3.4"},"reference-count":64,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,1,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Cisplatin-induced neurotoxicity and ototoxicity (NTX) are important adverse effects after chemotherapy for testicular cancer (TC). Although serum platinum is measurable years after therapy, its impact on NTX has not been evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> In all, 169 cisplatin-treated survivors of TC provided blood samples at Survey I and reported NTX during Survey I (1998-2002) and Survey II (2007-2008). Serum platinum was quantified by inductively coupled plasma mass spectrometry. Patient-reported outcomes were evaluated with the Scale for Chemotherapy-Induced Neurotoxicity (SCIN), regarding the extent of symptom bother as 0, \u201cnot at all\u201d; 1, \u201ca little\u201d; 2, \u201cquite a bit\u201d; or 3, \u201cvery much.\u201d Summing the six symptom scores yielded a total SCIN score of 0 to 18. Categorizing total SCIN scores into quartiles yielded similar-sized groups with increasing symptoms. Multivariate ordinal logistic regression analyses evaluated associations between NTX and long-term serum platinum levels, adjusting for cisplatin dose, dosing schedule, and age. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At Survey I, a significant four- to five-fold association with total SCIN score emerged for the highest serum platinum quartile (odds ratio [OR], 4.69; 95% CI, 1.82 to 12.08). Paresthesias and Raynaud's syndrome (hands and feet) showed significant two- to four-fold increased risks with the highest platinum quartile. At Survey II, total SCIN score remained significantly associated with the highest platinum quartile (OR, 4.28; 95% CI, 1.36 to 13.48). Paresthesias (hands and feet) and tinnitus showed significant three- to four-fold increased risks for the highest platinum quartile. Cumulative cisplatin dose was not associated with total SCIN score or individual SCIN symptoms in multivariate analyses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Here we document a significant relationship between increasing levels of residual serum platinum and NTX severity after adjusting for initial cisplatin dose. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.37.4025","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T04:51:33Z","timestamp":1324356693000},"page":"300-307","source":"Crossref","is-referenced-by-count":162,"title":["Impact of Long-Term Serum Platinum Concentrations on Neuro- and Ototoxicity in Cisplatin-Treated Survivors of Testicular Cancer"],"prefix":"10.1200","volume":"30","author":[{"given":"Mette","family":"Sprauten","sequence":"first","affiliation":[{"name":"Mette Sprauten, Milada Cvancarova, Sophie D. Foss\u00e5, and Jan Oldenburg, Norwegian Radium Hospital-Oslo University Hospital, Oslo; Hege S. Haugnes, University of Troms\u00f8 and University Hospital of North Norway, Troms\u00f8, Norway; Thomas H. Darrah, M. Ellen Campbell, and Robyn E. Hannigan, University of Massachusetts-Boston, Environmental Earth and Ocean Science; Clair Beard, Harvard Medical School, Dana-Farber Brigham and Women's Cancer Center, Boston, MA; and Derick R. Peterson and Lois B. Travis, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Darrah","sequence":"additional","affiliation":[{"name":"Mette Sprauten, Milada Cvancarova, Sophie D. Foss\u00e5, and Jan Oldenburg, Norwegian Radium Hospital-Oslo University Hospital, Oslo; Hege S. Haugnes, University of Troms\u00f8 and University Hospital of North Norway, Troms\u00f8, Norway; Thomas H. Darrah, M. Ellen Campbell, and Robyn E. 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Darrah, M. Ellen Campbell, and Robyn E. Hannigan, University of Massachusetts-Boston, Environmental Earth and Ocean Science; Clair Beard, Harvard Medical School, Dana-Farber Brigham and Women's Cancer Center, Boston, MA; and Derick R. Peterson and Lois B. Travis, University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milada","family":"Cvancarova","sequence":"additional","affiliation":[{"name":"Mette Sprauten, Milada Cvancarova, Sophie D. Foss\u00e5, and Jan Oldenburg, Norwegian Radium Hospital-Oslo University Hospital, Oslo; Hege S. Haugnes, University of Troms\u00f8 and University Hospital of North Norway, Troms\u00f8, Norway; Thomas H. Darrah, M. Ellen Campbell, and Robyn E. Hannigan, University of Massachusetts-Boston, Environmental Earth and Ocean Science; Clair Beard, Harvard Medical School, Dana-Farber Brigham and Women's Cancer Center, Boston, MA; and Derick R. Peterson and Lois B. 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