{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:58:41Z","timestamp":1791352721939,"version":"4.3.1"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,6,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Systemic anaplastic large-cell lymphoma (ALCL) is an aggressive subtype of T-cell lymphoma characterized by the uniform expression of CD30. The antibody-drug conjugate brentuximab vedotin delivers the potent antimicrotubule agent monomethylauristatin E to CD30-positive malignant cells. A phase II multicenter trial was conducted to evaluate the efficacy and safety of brentuximab vedotin in patients with relapsed or refractory systemic ALCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Patients with systemic ALCL and recurrent disease after at least one prior therapy received brentuximab vedotin 1.8 mg\/kg intravenously every 3 weeks over 30 minutes as an outpatient infusion. The primary end point of the study was overall objective response rate as assessed by independent central review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 58 patients treated in the study, 50 patients (86%) achieved an objective response, 33 patients (57%) achieved a complete remission (CR), and 17 patients (29%) achieved a partial remission. The median durations of overall response and CR were 12.6 and 13.2 months, respectively. Grade 3 or 4 adverse events in \u2265 10% of patients were neutropenia (21%), thrombocytopenia (14%), and peripheral sensory neuropathy (12%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Brentuximab vedotin induced objective responses in the majority of patients and CRs in more than half of patients with recurrent systemic ALCL. Targeted therapy with this CD30-directed antibody-drug conjugate may be an effective treatment for relapsed or refractory systemic ALCL and warrants further studies in front-line therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2011.38.0402","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T23:12:00Z","timestamp":1337641920000},"page":"2190-2196","source":"Crossref","is-referenced-by-count":883,"title":["Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Systemic Anaplastic Large-Cell Lymphoma: Results of a Phase II Study"],"prefix":"10.1200","volume":"30","author":[{"given":"Barbara","family":"Pro","sequence":"first","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana","family":"Advani","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Brice","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Illidge","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Matous","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Ramchandren","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fanale","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. 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Rosenblatt, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Tim Illidge, Christie Hospital National Health Service, Manchester, United Kingdom; Jeffrey Matous, Colorado Blood and Cancer Institute, Denver, CO; Radhakrishnan Ramchandren, Karmanos Cancer Institute, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Shustov","sequence":"additional","affiliation":[{"name":"Barbara Pro, Fox Chase Cancer Center, Philadelphia, PA; Ranjana Advani, Stanford University Medical Center, Palo Alto, CA; Nancy L. Bartlett, Washington University School of Medicine, St Louis, MO; Joseph D. 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